Construction Of Lipid/mesoporous Silica Composite Nanocarriers And Their Drug Release Properties

Resveratrol has been considered as the lead compound with natural antioxidants and cancer chemopreventive agents.However,its poor water solubility has greatly restricted its development.Solid lipid nanospheres(SLN)are nanotechnology-based drug delivery systems composed of biodegradable solid lipophilic matrix and encapsulated resveratrol in the lipid core,which can improve the bioavailability of resveratrol.Due to the high crystallization of solid lipid carriers,SLN has a series of disadvantageous properties including low loading capacity,burst release during the solidification and storage.Mesoporous silica nanoparticles(MSNs)as the drug carrier has become the new research focus in the field of nano-drug delivery system in these years because of the advantages of its construction stability,high loading capacity and so on.However,its biocompatibility is slightly worse when it compared with SLN.Dissolving the RES and lipid together and then filling the mixture into the channel of MSNs to prepare the RES-Lipid/MSNs,which can provide a new method to restrain the crystallinity of RES,improve the stability of the carriers and increase the bioavailability of RES.In this dissertation,MSNs were prepared by the method of modified St?ber and the RES-Lipid/MSNs were prepared by the mothod of emulsion evaporation and low temperature solidification.The micromorphology method,surface structure,phase characteristics,crystalline structure and thermal properties of RES-Lipid/MSNs were characterized.The loading capacity and particles polydispersity index of RES-Lipid/MSNs were discussed.The in vitro release behavior and the antioxidant properties of RES were evaluated.The microstructure of RES-Lipid/MSNs was spherical particles,the entrapment efficiency was(83.75 ± 0.73)%,loading capacity was(8.07 ± 0.03)%.The RES and lipid that incorporated into the channel of MSNs had an amorphous structure because of the adsorbent effect and spatial effect of MSNs.And the existence of lipid on the surface of MSNs could avoid the drug leakage.The release behavior of RES-Lipid/MSNs showed a obvious slow-release function.Compared with RES,the antioxidant activity of RES-Lipid/MSNs was improved distinctly.Combining the advantages of MSNs and the lipid,the composite nanocarriers of Lipid/MSNs were constructed in this paper.The Particle size distribution of RES-Lipid/MSNs was normal distribution.MSNs as a support frame could offer lipid a mechanical stability which could avoid the drug leakage and burst release,maintaining sustained release,improve the drug loading capacity as well as its antioxidant activity.The results showed a new technology for poorly soluble ingredients nanocrystallization,which would provide a scientific basis and a guidance for the composite nanocarriers with high bioavailability.