Synthesis And Biological Activity Of Novel Flavonol Derivatives

Taking the special character of flavonoids into consideration,synthetic routes were designed to afford thirty-seven phosphonate derivatives containing flavonoids unit,which through steps of separation,synthesis and purification.And then those target products had been identified by 1H NMR,13 C NMR,31 P NMR,IR and MS spectrum.The antibacterial activities of the all target compounds on Ralstonia solanacearum(Rs),Xanhomonas axonopodis pv.citri(Xac)and Xanthomonas oryzae pv.oryzae(Xoo)were tested by the turbidimeter test in vitro.The result showed that part of the target compounds exhibit better inhibition activities against Xoo and Xac than positive controls thiodiazole-copper and bismerthiazol(? 57.4%)at a concentration of 100 ?g/mL.The result showed that compounds I6,I8,I13,I22,I29 and I31 perform better inhibitions against Xoo at a concentration of 100 ?g/m L,all of which are more than 80%.The EC50 values of some of the target compounds as well as for bismerthiazol were presented,compounds I 1,I 6,I 8,I 13,I 19,I 20,I 21,I 22,I 27 and I 29 inhibited Xoo in vitro with the EC50 values of 66.63,40.29,43.07,17.38,50.07,66.87,65.73,22.78,40.62 and 16.47 ?g/mL,which are less than standard reagent Bismerthiazol(88.51 ?g/m L)in inhibition.Moreover,compounds I8?I24 and I27 moderate inhibitory activities against Xac.