Preparation And Application Of Core-shell Structure NP@MOF Nanocomposites

Metal-organic frameworks(MOFs)are a coordination of metal ions and organic ligands coordination of interesting class microporous crystalline materials.MOFs with easily adjustable pore structure and function,this is the result of different building blocks are available,and make them in molecular storage,separation,chemical sensors,catalytic,etc have widely application.More and more interest in sexual development of core-shell nanoparticles(NPs)@MOF composites material used to replenish NPs and molecular screening function of MOFs.With porous shell core-shell NP@MOF nanocomposites can prevent the aggregation and provides strong selectivity and reactivity.NP@MOF as functional materials in many applications,including chemical sensors,photoelectric,electronic equipment,and membrane potential attracted great attention the entire scientific community.The article includes three parts:Part one:IntroductionThis chapter content systematic introduces the NP@MOF nanocomposites synthesis methods and application of this material in various aspects.Furthermore,the application of NP@MOF mainly introduced including small molecule adsorption,storage,separation,catalysis,biological medicine,electrical,etc.Finally,the contents and significance of the research were proposed.Part two:Size-selective QD@MOF Core-shell Nanocomposites for the Highly Sensitive Monitoring of Oxidase Activities.Adenosine In this work,we proposed a novel and facile method to monitor oxidase activities based on size-selective fluorescent quantum dots(QDs)@MOF core-shell nanocomposites(CSNCPs).Core-shell CdTe QD@ZIF-8 nanocomposites have size selectivity,good stability,good dispersion liquid,and the synthetic method is simple,mild conditions,the advantages of the short time.The prepared CdTe QD@ZIF-8 CSNCPs,which have excellent water dispersibility and stability,displays distinct fluorescence responses to hole scavengers of different molecular sizes(e.g.,H2O2,substrate,and oxidase)due to the aperture limitation of the ZIF-8 shell.H2O2 can efficiently quench the fluorescence of CdTe QD@ZIF-8 CSNCPs,whereas large molecules such as substrate and oxidase have very little effect on its fluorescence.Therefore,the highly sensitive detection of oxidase activities was achieved by monitoring the fluorescence quenching of CdTe@ZIF-8 CSNCPs by H2O2 produced in the presence of substrate and oxidase,which is proportional to the oxidase activities.Therefore,the use of fluorescence spectrophotometry to test system,the content of oxidase in simple operation,greatly reduces the background fluorescence detection reagent used for interference detection system,to ensure the precision of the detection.This method has high sensitivity,strong anti-jamming capability,and stability good advantages,compared with double reagents used on automatic biochemical analysis instrument operation more convenient.The linearity ranges of the uricase and glucose oxidase activity are 0.1-50 U/L and 1-100 U/L,respectively,and their detection limits are 0.024 U/L and 0.26 U/L,respectively.Therefore,the current QD@MOF CSNCPs based sensing system is a promising,widely applicable means of monitoring oxidase activities in biochemical research.Part three:Lysozyme-Mediated Fabrication of Well-Defined Core-Shell Nanoparticle@Metal-Organic Framework Nanocomposites.We report a versatile strategy based on the use of self-assembled lysozymes(LYZ)to prepare core-shell nanocomposites with NPs in MOFs).We first demonstrated that LYZ can readily self-organize into a robust confonnal coating layer with abundant functional groups on the surfaces of various NPs,making it possible to direct the heterogeneous nucleation and growth of MOFs for the customized structural integration of a broad range of NPs and functional MOFs.Two kinds of core-shell NP@MOF nanocomposites with monocrystalline-shell and polycrystalline-shell structures are obtained dependent on the size of the NPs.The readily tunable structures added additional possibilities to tailor the functionalities of the nanocomposites by sandwiching nanostructures between the core and shell.When coupled with soft lithography,the LYZ-based method allows for fabricating the arrays of carbon dot(CD)@Tb-MOFs on a microscope glass slide with micro-sized resolution within minutes,which unlocked a possible opportunity for precisely engineering NP@MOF arrays on solid substrates.The proposed method shows competitive advantages including ease of interfacial functionalization,simple and mild conditions,and structure tunability for constructing NP@MOF nanocomposites,which have great application potential in many fields such as catalysis,sensors,biomedicine,and tissue engineering.