Preparation And Properties Of MOFS Composites Based On Prussian Blue

This study concentrated on the preparation,catalytic performance and drug-loading properties of Prussian blue-based MOFs composites and derivatives..Metal-organic frameworks(MOFs)containing catalytically active metal ions and functional organic linkages are ideal precursors for the preparation of bimetallic catalysts.The synthesis of hollow core-shell structures with different compositions has become a hot spot in recent years.MIL-101 has an ultra-high surface area,strong acid resistance and high stability,Prussian blue analogue Fe3[Co(CN)6]2(Fe?-Co PBAs)calcined to form a hollow porous derivative.The combination of multiple MOFs with controlled conditioning combines the best properties of materials to make them ideal for catalysts and drug carriers.This study mainly synthesizes the following kinds of materials:First,the Fe3[Co(CN)6]2(Fe?-Co PBAs)were synthesized by the static aging method.The crystals of HKUST-1 were uniformly deposited on the surface of Fe?-Co PBAs by solvothermal crystallization.The core-shell Fe?-Co PBAs@HKUST-1 composite was successfully prepared.By controlling the calcination conditions,its derived material CoFe2O4@CuO was obtained.The material was used to degrade p-nitrophenol and methylene blue in NaBH4 aqueous solution,and the kinetics of the degradation reaction was studied.Second,based on the Fe?-Co PBAs,Fe?-Co PBAs@MIL-101 composites with hollow structure were prepared by controlling the amount of FeCl3·6H2O and H2BDC in the solvothermal reaction.The drug loading properties of DOX in pH=7.4 phosphate buffer solution and drug release behavior at different pH values were investigated in Fe?-Co PBAs @ MIL-101 nanocage.Based on the systematic research,Fe?-Co PBAs with different morphologies and particle sizes could be prepared by controlling the amount of distilled water.The size of particles could be controlled between 100 nm and 1.2 ?m.At the same time,the catalytic performance of the calcined derivative CoFe2O4@CuO was also studied.The synthesized catalyst degrades 4-NP and methylene blue in water at room temperature.The results showed that the degradation reaction followed first-order kinetics.The degradation time of 4-NP and MB were 75 s and 50 s,respectively,and the rate constants k were 0.0406s-1 and 0.0534s-1,respectively.It indicates that the CoFe2O4@CuO derivative has high catalytic activity,especially for the degradation of methylene blue.Fe?-Co PBAs@MIL-101 nanocages with hollow structure were prepared by controlling the molar ratio of FeCl3·6H2O to H2BDC in the solvothermal reaction to be 1:3.The results showed that the drug-loading rate of anticancer drug DOX in PBS with pH=7.4 was 76%in Fe?-Co PBAs@MIL-101 nanocage.The cumulative drug release percentage of DOX in PBS at pH=7.4 was only 5.9%in 48 hours,the cumulative drug release percentage of DOX was 38%in PBS at pH=5.0,and the drug release was significantly higher than PBS at pH=7.4.Therefore,the material has great potential for cancer targeted therapy in cancer therapy.