Iron-catalyzed Insertion Reaction Of NH And SH Bonds Of Carbene

Diazo is one of the most important intermediates of organic synthesis,which is of great value in the fields of organic synthesis chemistry and drug design and development,chemical biology and material chemistry.The conversion of the traditional diazo reaction types including the Wolff rearrangement,via the transition metal carving or class carving intermediates insertion reactions,cyclopropane of catalytic reaction,and in recent years the development of transition metal catalyzed by carving intermediates of cross-coupling reaction against,etc.Diazo compound except as the precursor of carving a classic reaction,they can also through the transformation process of nitrogen group retention,retain in the target molecular diazonium group or other functional groups containing nitrogen atom.This strategy provides a highly efficient and selective constructing functional molecules containing nitrogen,especially nitrogen heterocyclic synthesis pathway of faculties.Among them,asymmetric c-n keys are selectively constructed.The assembly of asymmetrical nitrogen heterocyclic molecules still has important synthetic value and significant challenge significance.The research content of this paper mainly includes the following three parts:(1)Based on previous studies,our team synthesized several diazo carbonyl compounds.The compound has the advantages of cheap and readily available raw materials,relatively mild synthesis conditions,and high stability and non-deterioration.(2)Diazo ester compounds with several different substituents have been developed by changing the substituents of the starting materials used and optimizing the reaction conditions.(3)To explore the insertion reaction of N-H and S-H bonds of diazo compounds under iron catalysis.