Therapeutic Effect Of Qingre Jiedu Huazhuo Tablets Combined With Telbivudine On HBeAg-positive Chronic Hepatitis B (damp Heat Accumulation Syndrome)

Objective: Through joint for clinical observation of the detoxification method of Qingrejiedu Huazhuo sheet telbivudine treatment of chronic hepatitis Heat Accumulation Syndrome for Treatment of Chronic Hepatitis B Integrative Heat Accumulation Syndrome to provide a solution.Methods: 60 cases from Hunan University of Traditional Chinese Medicine First Affiliated Hospital Liver Center outpatient used Doll's clinical cases were randomly divided into treatment group and control group, 30 patients in each group. The control group received telbivudine antiviral therapy, the treatment group telbivudine treatment plus services on the basis of Qingrejiedu Huazhuo sheet, two observation period of 48 weeks. Before and after treatment were observed between the two sets of metrics and TCM symptoms and HBe Ag and seroconversion, HBV-DNA, liver function, and adverse reactions.Results:1.TCM Therapeutic Evaluation: treatment group total effective rate was 93.33%, control group effective rate was 76.67%, two groups are statistically significant(P < 0.05).2. Symptoms of TCM syndrome score: two groups after treatment of TCM symptom score decreased, compared with before treatment, were statistically significant(P < 0.05). After treatment, the treatment group in pain, languid, dry mouth, mouth pain, constipation, defecate viscous uncomfortable symptoms, such as the improvement of the superior to the control group, with statistical difference(P < 0.05 or P < 0.01).3. HBeAg negative conversion rate and HBeAg seroconversion rate: 2 groups of patients with HBe Ag negative conversion rate and HBe Ag seroconversion ratetreatment extended and increased, but 48 weeks in patients with HBe Ag negative conversion rate was no significant difference(P> 0.05).4. HBe Ag titers decreased ratio: two groups of HBe Ag percentage drops fell in 12 weeks and 24 weeks have statistical difference(P < 0.05), treatment group curative effect is higher than the control group. HBe Ag percentage drops fell at 48 weeks by comparing two groups has no statistical significance(P > 0.05).5. HBV-DNA response: two negative rate of HBV-DNA and HBV-DNA quantitative magnitude of the difference was no statistically decreased,(P> 0.05).6. Biochemical response: Biochemical response: After treatment, ALT, AST, TBIL levels than before treatment significantly decreased, with statistical significance(P <0.05), whereas no significant change in the level of ALB,(P> 0.05); ALT levels at 12 and 24 weeks, were significantly different(P <0.05) between the two groups. AST, TBIL no significant difference between groups,(P> 0.05).7. Liver fibrosis response: After treatment LSM value decreased compared with before treatment were statistically significant(P <0.01); and the test group decreased more than the control group, the two groups was statistically significant(P <0.05).8. Adverse reactions:both groups appear CK increased, the proportion of the treatment group CK elevated higher, approximately statistically significant(P = 0.052).Conclusion:DetoxificationHuazhuo sheet joint LdT treatment CHB patients can be improved to better improve liver pain, malaise, fatigue, dry mouth, mouth pain, constipation, stool viscosity unhappy better than single LDT.Detoxification Huazhuo joint Ld T reduce e antigen titer decreased serum CK ratio, the program can be improved HBe Ag-positive chronic hepatitis B HBe Ag loss and seroconversion, but no significant difference LDT alone.peculated the main pathogenesis may be hot and humid.