Molecular Dynamics Study On The Heat Release Characteristics Of Magnetic Induction Hyperthermia Nanoparticles

During the magnetic induction hyperthermia, Using magnetic nanoparticles as the heat medium to absorb energy of the external magnetic field convert to heat energy, then release into the organism.It can greatly improve the situation that traditional hyperthermia cannot reach the treatment temperature. Currently, the research on magnetic nanoparticles in hyperthermia mostly concentrated in the preparation of nanoparticles and the magnetic field generator. Research of the mechanism on magnetic nanoparticles improve of hyperthermia temperature mostly by using experimental method. Therefore, from the microscopic point of view to study the heat release characteristics of the magnetic nanoparticles during hyperthermia by molecular dynamics simulations is of great significance.There are many factors affecting the magnetic nanoparticles release heat, By analyzing the force which the magnetic received from the magnetic field, obtained the mathematic model of magnetic nanoparticles in magnetic hyperthermia, then got the molecular simulation model by using Materials Studio software and lammps software. Simulated two materials nanoparticles release heat with different size, different shape and different density of magnetic nanoparticles and different magnetic field strength. Found that during magnetic induction hyperthermia, The equilibrium temperature system can finally reach became higher with the higher concentration of magnetic nanoparticles and the bigger magnetic field strength values. The time required to reach the equilibrium temperature became shorter. With the same volume concentration, the system of which magnetic nanoparticles shape had the bigger specific surface area contained more energetic atoms, can reach the higher equilibrium temperature.