The Effect Of Eating Habits On Nonalcoholic Fatty Liver Disease And The Correlation Between TCM Syndromes And Blood Lipids And Blood Glucose

BackgroundNonalcoholic fatty liver disease(NAFLD)is a group of clinicopathological syndromes characterized by liver parenchymal cell steatosis and fat deposition,with no history of excessive drinking.With the improvement of people's living standard and changes of diets and lifestyle,the prevalence of NAFLD in China has been increasing year by year.However,the pathogenesis of NAFLD is not entirely clear,and may be the result of multiple factors.NAFLD is closely related to obesity,impaired glucose tolerance or diabetes,dyslipidemia and other metabolic risk factors,and may be related to dietary habits.ObjectiveTo investigate and study the clinical characteristics,dietary habits and TCM syndromes of NAFLD patients and analyze the relationship between diet and NAFLD,the relationship between TCM syndromes and blood lipid and blood glucose.Provide clinical advices and reasonable dietary guidance for NAFLD patients.Materials and methodsRecrui NAFLD patients and healthy volunteers from June 2016 to February 2017 at the China-Japan Friendship Hospital Health Examination Center.Respondents met the inclusion criteria and received a questionnaire survey.To collect the clinical data,test the serum biochemical indicators and carry out TCM syndrome differentiation of the subjects.Finally,a case-control study was used to perform statistical analysis.Results1.General informationA total of 118 valid data were collected.Among them,88 cases were case group and 30 cases were healthy control group.There were 54 males(61.36%)and 34 females(38.64%)in the case group,and the ratio of male to female was 1.59:1.The maximum age in the case group was 69 years,with a minimum of 23 years.The mean age in the case group was 42.26±11.29 years.The average age of men was 39.19±1.42 years,and the average age of females was 47.15 ±1.90 years old.As can be seen from the age structure,women were the most distributed in the 50-59 age group,accounting for 41.2%of the female patients,while the men were the most distributed in the 30-39 age group,accounting for 53.70%of the male patients.There was no difference in sex and age between the case group and the healthy control group(P = 0.848,P = 0.450).2.Body mass index(BMI)In the case group,21 cases were in the normal range,67 cases were higher than normal,of which 39 cases were overweight,28 cases of obesity.BMI was significantly higher in the case group than in the healthy control group(P = 0.000).3.Waist circumferenceThe number of effective cases of waist circumference in the case group was 84 cases(including 51 males and 33 females).In the case group of men,there were 7 cases in the normal range,6 cases in the central obesity pre-period,and 38 cases in the central obesity.In the case group of women,there were 5 cases in the normal range,8 cases in the central obesity pre-period,and 20 cases in the central obesity.The male and female waist circumference were significantly higher in the case group than in the healthy control group(P = 0.000,P = 0.007).4.Waist-to-ip ratioThere was no difference in waist-to-hip ratio between the case group and the healthy control group(P = 0.185).5.Biochemical IndicatorsLiver function(ALT,AST,GGT,ALP),blood glucose,blood lipid(CHO,TG,LDL-C)and uric acid in the case group were higher than those in the healthy control group(P<0.05 or P<0.01).The HDL-C level in the case group was significantly lower than that in the healthy control group(P=0.000).However,the mean levels of AST,GGT,ALP,DBIL,GLU HDL-C and UA in the case group were within the normal range,so there was no significant difference between the case group and the healthy control group.6.Dietary habitsCompared with the healthy control group,the case group showed a significant increase in food consumption frequency of eating meat and other foods,fried food,barbecued food,dried fried food,spicy food/seasoning(P<0.01).There was no difference in the regular diet,diet compatibility and the frequency of eating chili(P>0.05).7.The distribution of TCM syndromes in case groupSyndrome types from the multi-less followed by:damp-heat syndrome in 44 cases(50%),phlegm-dampness syndrome in 20 cases(22.73%),syndrome of phlegm and blood stasis in 16 cases(18.18%),spleen deficiency and dampness syndrome in 8 cases(9.09%).8.Comparison of blood glucose and blood Lipid levels between different types of NAFLDThe level of TG in the phlegm-dampness syndrome and damp-heat Syndrome was higher than that in the spleen deficiency and dampness syndrome(P=0.049,P=0.018).There was no significant difference in blood lipid and blood glucose between the other groups(P>0.05).Conclusion1.Obesity,especially waist circumference increases should be alert to the occurrence of NAFLD.From overweight and central obesity pre-period to strengthen the monitoring and early intervention.2.For NAFLD patients or high-risk patients should be advised to reduce intake of high-fat or high-protein foods;for healthy people advised to reduce intake of high-fat or high-protein foods to keep healthy.3.Sthenic syndrome may be the most common TCM syndrome in NAFLD.4.Phlegm-dampness and damp-heat syndrome of NAFLD are closely related to high fat diet.