| Objective:Through the establishment of MDS case data record,collected the clinical information of primary MDS hospitalized patients for the first time,from January 01,2006 to September 30,2016 in the Beijing University of Traditional Chinese Medicine Dongzhimen Hospital,Department of Hematology,summarizes the characteristics of TCM syndromes、the characteristics of traditional Chinese medicine、the characteristics of peripheral blood and the use of blood products in MDS treatment of patients with MDS in 10 years,Further statistics on the hematological characteristics of different ages,in order to provide hematology reference for the treatment of Chinese medicine,therefore,better guidance for clinical diagnosis and treatment of primary MDS are provided.Method:In this study,a retrospective clinical case study method was used to establish a unified information collection form for patients with MDS,from January 01,2006 to September 30,2016 in the Beijing University of Traditional Chinese Medicine Dongzhimen Hospital,Department of Hematology.using SPSS20.0 software for statistical analysis.Results:1.Patients of primary MDS with other diseases combined,followed by heart disease,hypertension,diabetes,pulmonary infection,esophagitis,chronic gastritis,cerebrovascular disease,liver dysfunction,dyslipidemia,Osteoporosis,the largest proportion of cardiovascular disease among theses comorbidities,53.97%,especially among the over 65-year-old population,accounting for 77.94%.2.The 15 major clinical symptoms of MDS patients were as follows:body tired fatigue(90.48%),pale tongue(66.67%),mental fatigue(65.08%),dry mouth(44.44%),shortness of breath and voice low(42.06%),white/chlorosis complexion(36.51%),dizziness(34.13%),subcutaneous purpura/bleeding(33.33%),upsetting disturbances(32.54%),bleeding symptoms(30.95%),emaciation(28.57%),hot flashes and night sweating(27.78%),spontaneous sweating(22.22%),dark complexion(22.22%),lack of energy(18.25%).3.The most occurrence of single TCM syndrome of primary MDS patients was qi deficiency syndrome with 85 times(67.46%),the rest of the syndrome from high to low were as follows:blood deficiency syndrome is 38 times(30.15%),yin deficiency syndrome is 36 times(28.57%),blood stssis is 33 times(26.19%),toxic heat syndrome is 8 times(6.34%),yang asthenia is 4 times(3.17%).4.All syndromes of primary MDS patients,qi and blood deficiency syndrome is the most occurrence of 24 times(19.05%),the rest of the syndrome from high to low were as follows:qi deficiency syndrome accounting for 12.70%,qi and yin deficiency syndrome accounting for 12.70%,qi deficiency and blood stssis syndrome accounting for 8.73%,Qi and Blood Deficiency and Blood Stasis Syndrome accounting for4.76%,Qi and Yin deficiency and blood stasis syndrome accounting for4.76%,Yin deficiency and blood stasis syndrome accounting for 3.97%,blood deficiency syndrome accounting for 2.38%,Yin deficiency syndrome accounting for 2.38%,Qi and yang deficiency syndrome accounting for 2.38%,Qi deficiency and toxic heat Syndrome accounting for 2.38%,Yin deficiency and toxic heat Syndrome accounting for 2.38%,Blood stasis syndrome accounting for 1.59%,Blood and Yin deficiency syndrome accounting for1.59%,Yang deficiency and blood stasis syndrome accounting for0.79%,qi and blood deficiency and toxic heat Syndrome accounting for0.79%,Blood and Yin deficiency and blood stasis syndrome accounting for 0.79%,Yin deficiency and toxic heat and blood stasis syndrome accounting for 0.79%,qi and blood deficiency combined with Yin deficiency blood stasis syndrome accounting for 0.79%.there were 18 cases of No obvious evidence of the performance,accounting for 14.29%.5.In this study,there were 123 patients with varying degrees of hemoglobin decreased,of which only 1 case of severe anemia,the rest were slight to severe anemia.There was no statistical significances of difference in the degree of anemia between different age groups,so we would not be consider that there was difference in the distribution of anemia among different age groups.There was no statistical significances of difference in the HGB numerical value among different age groups,furthermore,no correlation was found between age and HGB numerical value in the Pearson rank correlation coefficient analysis.6.In this study,the most occurrence of three series blood cells decreased,different age groups of blood cell reduction were compared,there was no statistical significances of difference,still can not be considered that there are differences between different age groups.7.There were 114 cases who wrer taking traditional Chinese medicine decoction,accounting for 90.48%,a total of 183 Chinese medicine applied,in which the major proportion of the application were Hematinic,reinforcing qi,Yin tonifying herbs and blood-activation Chinese medicine,According to the frequency of Chinese medicine appeared,the 15 major from high to low were as follows:Rehmanniae(82.46%),Codonopsis(79.82%),Rehmannia glutinosa(75.44%),Caulis Spatholobi(73.68%),Radix Astragali(71.93%),Salvia(71.05%),Angelica(69.30%),Dodder(54.39%),safflower(41.23%),earthworm(39.47%),raw Astragalus(35.96%),turtoise-plastron glue(34.21%),Poria cocos(32.46%),Atractylodes(31.58%),licorice(26.32%)。Conclusions:1.The most occurrence of single TCM syndrome of primary MDS patients was qi deficiency syndrome,the rest of the syndrome were as follows:blood deficiency syndrome,yin deficiency syndrome,blood stssis syndrome,toxic heat syndrome,yang asthenia;The most occurrence of all syndromes is qi and blood deficiency syndrome;Suggesting that primary MDS mainly based on qi and blood deficiency,while qi and blood have mutual effect or actions,So clinical application of traditional Chinese medicine treatment should pay attention to homology of qi and blood,tonifying qi for replenishing blood.Compound syndromes were as follows:qi and blood deficiency syndrome,qi and yin deficiency syndrome,qi deficiency and blood stssis syndrome,Qi and Blood Deficiency and Blood Stasis Syndrome,Qi and Yin deficiency and blood stasis syndrome,Yin deficiency and blood stasis,Qi and yang deficiency syndrome,Qi deficiency and toxic heat Syndrome,Yin deficiency and toxic heat Syndrome and so on.Indicating that the main virtual of primary MDS patients is deficiency in origin,and often mixed with enrichment in symptom in the course of the disease,the Application of TCM treatment should pay more attention to the relationship of reinforcing deficiency and reducing excess、strengthening healthy and eliminate pathogens,taking the actual situation of the health and pathogen for reference,do not commit the false of reducing deficiency and reinforcing excess.2.There was no significance difference in the distribution of anemia among different age groups.There was no significance difference in HGB among different age groups,meanwhile,there was no correlation was found between age and HGB numerical value.There was no statistical significances of difference between different age groups of blood cell reduction.The condition is serious at any age,Peripheral blood cell reduction is the general characteristics of primary MDS patients,Anemia,bleeding and infection are common clinical manifestations of MDS patients,dyahaematopoiesis is the most important morphological features.3.Clinical application of TCM,which the major proportion of the application were Hematinic,reinforcing qi,Yin tonifying herbs and blood-activation Chinese medicine;The formulas of Yisui granule in accordance with MDS characteristics,there are great value under the guidance of principles of formulating prescription of Yisui granule,using Yisui granule with the addition and subtraction in clinical MDS treatment. |
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