Clinical Study Of The Pathogenesis And Pathogenesis Of Prostate Cancer-associated Cerebral Infarction

Objective To study the clinical features of ischemic stroke in patients with prostate cancer.Methods The clinical data of prostate cancer with acute ischemic stroke in First Affiliated Hospital of Guangxi Medical University from January 2003 and December 2015 were retrospectively analyzed.Out of 2584 cases of prostate cancer patients,34 patients were suffered from acute ischemic stroke(1.31%),with an average age of(61.60±6.28)years.Among the 34 patients,21 patients(61.76%)lacked of the conventional risk factors for ischemic stroke.Blood biochemistry tests showed 22 patients(64.71%)with an elevated plasma D-dimer levels and 19 patients(55.88%)with a significantly elevated levels of the total prostate specific antigen(>100ng/ml).And the magnetic resonance imaging examinations showed 8 patients(23.52%)with single lesions,and another 26 patients(76.47%)with two or more lesions distributed to multiple cerebral arterial regions.At the 30 th day,most of the prostate cancer patients with acute ischemic stroke were found with poor prognosis,and 3 patients(8.82%)died.Conclusions It was suggested that the ischemic stroke associated to prostate cancer had distinct clinical features such as without the conventional risk factors,with an elevated plasma D-dimer levels and with a significantly elevated levels of T-PSA,and with multiple lesions distributed to multiple cerebral arterial regions.And the pathogenesis might relate to blood hypercoagulability.Objective To study the probably pathogenesis of prostate cancer-associated ischemic stroke,so as to make a further clinical understanding of the disease.Methods 23 prostate cancer-associated ischemic stroke patients who were admitted to The First Affiliated Hospital of Guangxi Medical University from January 2003 to December 2016 were retrospectively recruited as prostate cancer-associated stroke group(PSG).At the same time,92 prostate patients lacked of conventional risks for stroke(CRF)were consecutively recruited in a ratio of 1:4 as prostate group(PG)matched with the PSG on age,gender and time.Clinical data of two groups were collected and analyzed.Results The average age was(65.09±6.75)years of the PSG,no significant difference between the two groups in age.All of the patients in PSG were lacked of conventional stroke risk and were undetermined etiology of ischemic stroke,10 patients(43.5%)occurred ischemic stroke after prostate cancer confirmed,16 patients(69.6%)were found with the multiple infarction focuses in multiple vascular territories.Compared to the PG,the PSG had a higher rate of metastasis,higher level of gleason score,and more patients in the PSG were given surgery and medicine androgen deprivation therapy(ADT)after surgery(p<0.05).The D-dimer,total prostate specific antigen,platelet count of the PSG were significantly higher than the PG(p<0.05).While there were no difference in hemoglobin,CA125,CA199,CEA,AFP,PT,TT and APTT between the two groups.A further logistic regression analysis of multiple factors showed that,the level of D-dimer,T-PSA were the independent risks for prostate cancer-associated ischemic stroke.Conclusions It was suggested that prostate cancer with significantly high level of D-dimer and T-PSA might be the biomarkers of prostate cancer-associated ischemic stroke,and might probably relate to the pathogenisis of these patients.