An Ecological Statistical Analysis Of Intestinal Microflora In Human Colorectal Cancer

Colorectal Cancer(Colorectal Cancer,CRC),for its fatality,is one of the common malignant tumor by medical scientists.By previous researches,it is proved that any change of the gut microbiota composition may promote the progression of CRC.So it can become a sensitive signal of a certain disease.However,about whether the maintenance mechanism of the gut microbiota is relating to the colorectal cancer or not,the corresponding answers are few known.From an ecological and statistical perspective,in this paper,the diversity and distribution of microbial communities in colorectal cancer tissues are statistically analyzed:First,by applying the ordinary liner model and the Taylor power law extension model,we study the spatial heterogeneity(heterogeneity of interspecific and intraspecific heterogeneity)of the microbial community of the colorectal cancer patients’ tissues.We part two steps for this study.First,comparisons between 8 patients’ cancerous tissues and the adjacent healthy tissues of the same persons are performed.Second,comparisons between 46 patients’ cancerous tissues and the same tissues from 56 healthy people are done.It is to investigate that whether the changes in spatial heterogeneity of the microbial community of the tissues can be a reason of the colorectal cancer breaking up.Second,by applying the Ewens and Etienne sample methods,the neutral test are carried for the sampled data of the cancerous tissues and the adjacent health tissues of the 8 colorectal cancer patients,as well as the same test for the 46 colorectal cancer patients and the 56 healthy people.By using the chi-square test we compares the two methods and summary the neutral rate,and then we take an analysis for the fundamental diversity index in the neutral model and the Simpson diversity index,and then we investigate the relationship of the two diversity index.The regression,test,estimation and other relevant statistical methods are applied to ecology in the field of colorectal cancer related to the intestinal microbial community in this research.We try to explore the community assembly and diversity maintenance of the new environment in the gut microbiome.The results show that the heterogeneity and diversity have changed in the cancer group,comparing with the control group.The preliminary results is significant for further research on the ecological statistics related to intestinal microbial disease.