The Quantitative Diagnosis Of TCM Syndrome Differentiation Of Nonalcoholic Fatty Liver Disease And The Study Of The Law Of Drug Use In Literature

Purpose: 1.Study on TCM symptoms and signs of non-alcoholic fatty liver disease,summarize the characteristic symptoms of eatch type of syndrome.2.Explore the compatibility rule of traditional Chinese medicine in the treatment of non-alcoholic fatty liver.Material and method: Retrieve the literature on the treatment of non-alcoholic fatty liver by Chinese medicine published in China over the past decade(from January 2006 to October 2016),as a way to retrieve the keywords such as “non-al-coholic f-atty liver disease,evidence-based medicine and syndrome differentiation type,medical record,the typical cases,traditional Chinese medicine” including CNKI,VIP and Wanfang database.Pick out the related literatures 301,which about TCM syndrome differ-entiation and treatment of traditional Chinese medicine,remove dup-licate and irreleva-nt literature.According to the literature into the exclusion criteria,a totally of 121 documents were obtained.In the 121 literatures,there are 36 articles about the classific-ation of syndrome differentiation,involving 5138 cases.In the 101 clinical research a rticles of prescription,compound prescription or empirical prescription,20 clinical rese-arch articles were treated by method,summed up the 65 doctors of their own syndro-me differentiation experience.Find out the results of the disease on the classification of syndrome differentiation.Two factor Logistic ste-pwise regression(forward LR)ana-lysis was used to screen the related factors,use Zhu Wenfeng's Syndrome Differentia-tion Method provisions in the "common symptoms metrology diagnosis" to identify common factors related to syn-drome,and in order to establish the diagnostic table of common symptoms of non-alcoholic fatty liver disease.Screening for typical case,seni-or experts of medical records and TCM syndrome differentiation and treatment of the literature 106,those about non-alcoholic fatty liver disease treated with traditional Chin-ese Medicine.To further explore the compatibility rule of single syndrome.Results: 1.This article draws the common syndrome differentiation of non-alcoholic fatty live di-sease,those who followed by phlegm and blood stasis,stagnation of liver-QI with de-ficiency of the spleen,accumulation of phlegmwetness in the body,qi-stagnancy andb-lood stasis,endoretention of damp heat,stagnation of QI due to depression of the liv-er.2.The factors related to the measurement of different syndromes of nonalcoholic fattyliver were showed as follows.(1)Phlegm and blood stasis includes rib pain,breast lump,dark complexion;and see the chest epigastric fullness,anorexia,disgusting,greasy body.Dark red tongue with ecchymosis,with scalloped edges,greasy moss,pulse string slide.(2)Stagnation of liver-QI with deficiency of the spleen includes flank pain,fatigue,irritability,abdominal pain and abdominal distention,see;nausea,anorexia,or s-igh.Pale tongue,white and greasy fur,with teeth marks,pulsestring.(3)Accumulation of phlegmwetness in the body includes the body fat,flank pain,body weight,stool vi-scosity;and see abdominal distention,fatigue,anorexia,nausea,dizziness.The tongue is thin and fat,the moss is white and greasy,and the pulse is smooth.(4)Qi-stagnan-cy and blood stasis includes flank pain,chest stuffiness,hepatosplenomegaly,irritabilit-y;and see fatigue,anorexia and abdominal distension.Dark tongue,petechiae,moss white greasy,pulse string slide.(5)Endoretention of damp heat includes flank pain,abdominal distension,stool viscosity;and see the skin stained yellow,yellow urine,mou-th sticky,dry mouth,bitter taste.Red tongue,yellow greasy moss,pulse string slide.(6)Stagnation of QIdue todepression of the liver includes liver pain,irritability,flank p-ain,chest tightness,or sigh;and see the occasional belch,anorexia,abnormal stool.Red tongue,thin white fur,wiry pulse.3.Chinese medicine treatment of non-alcoholic fatty liver involves 142 kinds of drugs,36 small classes,8 major categories.The drugs used were focused on expel water and dampness,tonic class,regulate the flow of vital energy and remove obstruction toita-nd help to digest.But enrich the blood,invigorate the circulation of blood,remove d-ampness through dieresis and clearing heat were also have higner use rate.4.Preliminary obtain a result about the rules of the common type of non-alcoholic fatty liver disease.Syndrome of intermingled phlegm and blood stasis multi use invigorate the circulation of blood circulation,expel water and dampness,regulate the flow o-f vital energy and remove obstruction toit and Tonic classes;Syndrome of stagnation of liver qi and spleen deficiency multi use invigorate the circulation of blood circulate-on,regulate the flow of vital energy and remove obstruction toit,tonic classes and expel water and dampness;Phlegm dampness syndrome multi use expelwater anddampn-ess,tonic classes,invigorate the circulation of blood circulation;Damp heat connotation certificate multi use expel water and dampness,invigorate thecirculation of blood c-irculation and heat clearing drugs;Liver depression and qi stagnation syndrome multi use invigorate the circulation of blood circulation,expel water and dampness,heat clearing drugs and regulate the flow of vital energy and remove obstruction toit.5.The order of application of drugs for nvigorating the circulation of blood were Dans-hen,Yujin,Chuanxiong,Taoren,Jianghuang,Zelan,Honghua;The order of applicatio-n of drugs for expelling water and dampness were Zexie,Fuling,Banxia,Heye,Huzhang,Yin-chen,Cangzhu,Houpo,Yiyiren;The order of application of drugs foregulati-ng the flow of vital energy and removing obstruction toit were Chenpi,Zhiqiao,Zhis-hi,Xiangfu,Qingpi,Chuanlianz;The order of application of drugs for toifying were Baizhu,Baishao,Danggui,Heshouwu,Huangqi,Dangshen,Gouqizi,Huan-gjing;Theorder of application of drugs for clearing heat were Juemingzi,Chishao,Xiakucao,Huan-glian,Huangqin,Mudanpi,Banlangen,Baijiangcao;The order of application of drugs for digesting were Shanzha,Laifuzi,Jineijin,Shenqu;The ordeof application of drugs for relieving were Chaihu,Gegen,Guizhi,Shengjiang;The order of applicationofdrugs for purgativing were Dahuang,Huomaren,Yuliren.Conclusion: 1.In this paper,through the study of TCM Syndromes of NAFLD,we derived the characteristics of non-alcoholic fatty liver common syndromes,jointly the established 6 q-uantitative diagnostic tables,the differentiation type of the disease was obtained.2.The results of this article obtained the rule of medication,roughly covers the main principles at present the medical treatment on non-alcoholic fatty liver disease,dampen-ss,phlegm,activating blood and soothing liver and tonifying spleen,with different tre-atments according to different symptoms and signs.3.Non-alcoholic fatty liver treatment has a widely used in medicine,the doctors carry out temporary and permanent solutions of parallel principle,drive out evil spirits and simultaneously tonifying Qi and blood.