Preparation Process, Quality Control And Pharmacodynamics Study Of Gemini Enteric-coated Capsules

Purpose:Enteric-coated capsule by Gemini(fried)cassia,Plantago composed of two traditional Chinese medicine.Psyllium flavor is sweet and cold.Liver,kidney,lung,intestine,tonglin has the effect of diuretic,expectorant,blood-cooling and detoxifying effect.Cassia tastes sweet,bitter,salty and slightly cold.Liver,large intestine,has the effect of improving eyesight,laxative effect [1].Contains anthraquinones of Cassia is the main components of the drastic effect of Cassia.Methods and Results:1.Gemini enteric-coated capsule preparation technique.Enteric-coated capsules of Gemini study on extraction technology of cassia,orthogonal,liquid alcohol concentration ratio,extraction and extraction times on extraction of effect,optimized Gemini enteric-coated capsules in the optimum extraction technology of Cassia.2.Quality Standards of Esomeprazole sodium for injection.Established by high performance liquid chromatography and ultraviolet Spectrophotometric method for the determination of main components and the study of the methodology of the determination method of double notes.3.Gemini enteric-coated capsule on pharmacodynamics of constipation mice.Establishment of constipation mice developed experimental methods,visit first time black stool,in the small intestine of mice ink rate,excreta moisture,moisture in the intestinal content and grain number 5h bowel,and other factors.Results:1.Select 70% as cassia seed extract solvents of ethanol,adding alcohol amount 6 times,1.5 hour/time,determine the optimal extraction process.2.By high performance liquid chromatography and ultraviolet Spectrophotometric method for enteric-coated capsules of Gemini principal components and related indicators were measured result full compliance with standards.3.Gemini enteric-coated capsule reduces constipation mice first time black stool,increased small intestine ink rate,improved manure and water in the intestines,increase bowel movements in the 5h number.Conclusion:Through the study of enteric-coated capsules of Gemini,Gemini enteric-coated capsule formulation process is determined,establish quality standards,through pharmacodynamic study of constipation mice,proving that Gemini enteric-coated capsule can promote intestinal peristalsis,improving water in the intestine and has a laxative effect.