Exploring And Experimental Research On The Cold And Hot Medicinal Properties Of Traditional Chinese Medicine, Asahi And Maca

BackgroundIn ancient times,there were many Chinese herbal medicines originating from abroad,and under the globalization of economic and trade,China's reform and opening up,and the "One Belt and One Road" policy of Chinese medicine,a large number of excellent "new foreign resources" with strong biological activity such as Acai and Maca,it is appearing in different forms in the Chinese market,and the most pressing task is to seek a path of "New Foreign Resources" and "Turn It Chinese Herbal Medicine" and form a research model in order to use a more rational way of "Turn It Chinese Herbal Medicine" into compatibility with existing Chinese medicines.Applied to the clinical,play its value and role.This requires us to imitate the ancients,under the guidance of traditional and modern Chinese medicine theories,through modern techniques and methods,to give“New Foreign Resources " Chinese medicine and Chinese medicine efficacy,so that "ancient for the present;foreign for the use."Acai(Euterpe Oleraceae Mart.)is derived from the fresh fruit of the palm tree of the palm plant.Palla,Maranhao,Tocantins,Amapa and Guyana and Venezuela,which are mainly distributed in the Amazon basin,are a kind of South American traditional Herbal medicine that have been applied for centuries.According to records of traditional medicine in South America such as Brazil and Peru,Acai can be used to treat diarrhea,skin ulcers,fever,diabetes,hair loss,hemorrhage,liver disease such as hepatitis,jaundice,kidney disease,malaria,irregular menstruation,menstrual pain and muscle soreness.The effect is significant.Maca(Lepidium meyenii Walp.)is an annual or biennial herbaceous plant of the family Cruciferae.It is native to the Andean region of South America with an altitude of 4,000 to 4,500 meters.It is one of the commonly used medicinal and edible plants in the region,with high nutritional value and unique medicine.Use value can be used to strengthen the body,improve immunity,improve sexual function,anti-depression,anti-anemia,etc.,and thus has the reputation of "South American ginseng".At present,Maca has been widely used as a plant medicine in the world,and various reports on its chemical composition,biological activity and clinical application have also been reported.Acai and Maca were approved by the Ministry of Health in 2013 and 2011 respectively to be allowed to be used as new resource foods in China.At present,there are many kinds of products that are compatible with traditional Chinese medicines appear on the market.Based on the traditional application and research literature,the research group proposed the Chinese medicinal Property of Acai and Maca under the guidance of Chinese medicine theory.That is,the Cold and Heat Property of Acai are "Cool",and the Five Tastes are "Sour and Sweet",and the channel tropism are "spleen,liver,and kidney";its efficacy is Spleen Qi,nourishing liver and kidney,blood circulation.the Cold and Heat Property of Maca are "Neutral biased towards Warm",and the Five Tastes are "Sweet and Spicy",and the channel tropism are "spleen,liver,and kidney";its efficacy is Kidney Essence,strong gluten and bone,Dredge the liver to relieve blockage.ObjectiveIn this study,the "New Foreign Resources",ie,Acai and Maca,were taken as examples to carry out literature,theoretical and experimental research with the Cold and Heat Property as the entry point.The study of Acai,based on the close follow-up of its modern research progress,comprehensively collates the research literature with database technology,according to the traditional clinical application of origin and modern research literature reports,according to the first time the research group proposed the traditional Chinese medicine properties,A systematic theoretical analysis of Chinese medicine was conducted and the Cold and Heat Property were deduced;the results of pharmacological validation were deduced.The study of Maca was based on the Chinese and foreign literature database established by the research group and the proposed Chinese medicine propertie,and the pharmacology verified the Cold and Heat Property.MethodsApplication of Microsoft Access 2013 software to establish the database of "Chemical composition-biological activity-targets" of Acai and use it as a research tool,?The results of clinical trials,animal experiments,cell experiments,and chemical composition study were analyzed.According to the theory of traditional Chinese medicine,the cold and hot medicinal properties of Acai were explored.? From the traditional method of "taking analogy and figuring like",based on the theory of the Five Elements,the authors analyzed the vegetation characteristics,growth environment,and traditional application records of the Acai and discussed the Cold and Heat Property of Acai.? Starting with the active ingredients described in the chemical composition study of Agai,search and summarize the existing traditional Chinese medicines containing this ingredient,and search for the Cold and Heat Property of traditional Chinese medicine,and use statistical data to explore the use of big data.The thinking predicts the Cold and Heat Property of Acai.A Dexamethasone DH(Deficiency-Heat)Rat Model and a Hydrocortisone DC(Deficiency-Cold)Rat Model were established.The traditional cold-cold drug Phellodendron and warm-blooded cinnamon were used as positive controls.The traditional cold medicine Phellodendron chinense and warming medicine cinnamon were used as positive controls.Through the comparison of similar species and different types of anti-evidence,the trends of biological characteristics of animals were examined to verify the Cold and Heat Property of Chinese traditional medicines such as Acai and Maca.Results1.Literatures research and Theoretical discussion1.1 Foreign Literatures Research on AcaiThere are a total of 98 literatures available abroad in Acai.A total of 10 clinical trial studies were conducted.The main contents of the study were antioxidant and anti-inflammatory,improved cardiovascular function,lipid-lowering,hypoglycemic,and enhanced physical conditioning of the body;A total of 37 animal experiments were conducted.The main contents of the research were antioxidant,anti-inflammatory,anti-cancer,lipid-lowering,hypoglycemic,anti-arteriosclerosis,liver protection,kidney maintenance,immune regulation,treatment of neurodegenerative diseases,and antibacterial activity;A total of 24 cell experiments were conducted.The main contents of the study were antioxidant,anti-inflammatory,anti-cancer,lipid-lowering,immune regulation,neuroprotecti--on,and anti-osteoporosis;There are a total of 27 chemical composition studies,of which 181 can be detected chemical components,a total of 54 species with strong biological activity(including 4 domestic documents)and 9 major components,That is,the pharmacological chemical constituents can be retrieved through the CNKI literature database.1.2 Domestic Literatures Research on AcaiThere are a total of 9 literatures available in Acai.A total of 7 animal experimental studies were conducted.The main contents of the study were liver protection,anti-oxidation and anti-radiation;There are a total of 2 chemical composition studies,and there are a total of 2 types and 7 types of chemical compositions described in the literature,and a total of 4 types that have strong biological activity,That is,the pharmacological chemical constituents can be retrieved through the CNKI literature database.1.3 Acai Cold and Heat Property discussion and predictionBased on the results of Acai clinical research,animal,cell and chemical experiments were used as evidence,combined with the traditional Chinese medicine theory,and the efficacy of Acai was deduced from the etiology,pathogenesis,main card,and treatment method.Spleen Qi,nourishing liver and kidney,blood circulation to reduce the effectiveness of turbidity;further localization of organs,derivation into the spleen,liver,kidney;According to the effectiveness of the derivation of its Sour and Sweet;According to its overall adjustment role bias,cold and hot,The heat is cold,deducing its sexual bias "Cool" or "Slightly cold";according to channel tropism to deduced the tendencies are descending.By taking an analogy approach,it is believed that the Acai color purple is a water of the Five Elements,which enters the kidney and is cold,was born in the tropics,can be consumed in large quantities daily,and has records of the treatment of hot diseases.Thinking the the Cold and Heat Property of Acai are"Cool"or"Slightly cold".Starting from the stronger active ingredients described in the study of the chemical composition of Acai,the existing Chinese medicines containing the ingredients were collected,and a total of 2,644 records were recorded.Among them,herbal medicines with Cold and Cool Property account for a large proportion,accounting for about 52%of the entire record.While the Neutral Property accounted for 26%,and the Warm and Heat accounted for 22%.Therefore,it is predicted that the medicinal properties of Agai tends to Cold2.Experimental research2.1 Acai Cold and Heat Property VerificationBody weight,cyclic nucleotide levels(cAMP,cGMP),metabolic levels(TP,ALB,UA,GLU,TC,TG,FFA,LPL),immunity levels(IgG,IgM,C3,C4),hormone levels(The biological effects of T3,T4,rT3,CORT,E2,T)and neurotransmitters(NE,DA,5-HT)were examined.According to the results,it is considered that Acai can effectively improve the state of the DH model rats,but not able to improve its state of DC,and it even exacerbated some of the changes in indicators,so it was similar to the tendency of CP(Cortex Phellodendri)as a whole and contrary to the trend of CC(Cortex Cinnamomi).However,the partial immune and hormonal indexes in rats with DH Model and DC Model showed two-way adjustment.2.2 Maca Cold and Heat Property VerificationBody weight,cyclic nucleotide levels(cAMP,cGMP),metabolic levels(TP,ALB,UA,GLU,TC,TG,FFA,LPL),immunity levels(IgG,IgM,C3,C4),hormone levels(The biological effects of T3,T4,rT3,CORT,E2,T)and neurotransmitters(NE,DA,5-HT)were examined.From the results,Maca has a certain degree of two-way regulation of some metabolic levels,immune levels,and some hormones in rats with DC Model and DH Model,and in some indicators was similar to that of CC,which was contrary to the tendency of CP.Conclusions.1.Literatures research and Theoretical discussionAccording to the results of the literature research and the derivation of the theory,it is believed that the acai the Cold and Heat Property of Agai are "Cool",and the Five Tastes are"Sour and Sweet",and the channel tropism are "spleen,liver,and kidney";the tendencies are descending;its efficacy is Spleen Qi,nourishing liver and kidney,blood circulation.2.Experimental researchAcai and CP similar trends,and have a certain degree of regulation of immune function,it is not the "Big cold" of the drug,its nature biased to "Cool" or "Slightly cold",and its experimental results of traditional Chinese medicinal properties were in line with the theoretical discussion.Maca has a certain degree of biphasic regulation of some metabolic levels,immune levels,and some hormones in rats with DC and DH models.In some indicators,the trend of CC is similar.The Cold and Heat Propertys tends to be "Neutral biased towards Warm",and its experimental results of traditional Chinese medicinal properties were in line with the theoretical discussion.