In Situ Repair Of Bone And Cartilage Defects Using 3D Scanning And 3D Printing

As a rapidly developed technology,3D printing had an influence on many areas,such as automobiles,astronautics,machinery,medical care and education.It even made a revolution of the biomedical engineering,which was going to be commercialized.In some situation,3D bioprinting may have the potential in treating orthopaedical disease.However,simply using a device such as a bioprinter cannot complete the task of tissue reorganization.It was necessary to combined cytology,clinical medicine,material science,physics,and analytical chemistry all together.In this study,3D scanning technology and 3D printing technology were used to get the digital data of the simples and to perform in situ printing on the fabricated areas of bone and cartilage,and to explore the feasibility of 3D in situ printing in these model of orthopedic diseases:a.Long bone defect model;b.Femoral condylar irregular fracture model;3.Cartilage defect model(according to the International Cartilage Repair Association(ICRS)definition of IV Cartilage defect).A sample model(including a health model and a disease model)was constructed using a high-resolution three-dimensional scanner,and then a geometric model of the defect site was obtained through a Boolean logic operation.Then the target model was imported into the 3D printer.Bio ink used in this study were two different photopolymerized hydrogels.After printing,the simples were underwent the 3D scanning another time for further comparation with the original ones.Finally,the defective bone and cartilage were successfully repaired.The results of this study suggest that 3D scanning and 3D printing can provide new therapeutic ideas for tissue engineering and regenerative medicine.