Individual Haemodynamics Simulation And Analysis Based On The Finite Element Method

Diabetes mellitus(DM)is a predisposing factor leading to macrovascular diseases and plays a pivotal role in the formation of early atherosclerosis.However,computational analyses are lacking to interpret changes in haemodynamics of the diabetic aortas.Recently,the finite element method is widely used in the study of haemodynamics.In this paper,based on the results of the CTA images and ultrasound measurement in the non-diabetic and diabetic rabbit decending aortas we performd the three-dimensional modeling reconstruction and finite element calculation.And then we analyzed the haemodynamic of rabbit descending aorta through post-processing and visualization processing.Moreover,the simulation results played a supplementary role in the research of diabetic haemodynamics effect and formation mechanism in the descending aortas.Ten adult rabbits(1.6-2.2 kg)were collected and the type I diabetic rabbit model was induced by injection of alloxan.A total of 5 control and 5 diabetic rabbit aortas were considered for subsequent numerical simulation.The CT scanning was performed to reconstruct three-dimensional model of the individual rabbit descending aorta.The flow waveforms were measured by ultrasound machine and were set to be the boundary conditions of velocity.The reconstructed aortas were then imported into ANSYS to perform mesh generation and computational analysis.The results showed that the distributions of haemodynamic indicators(TAWSS,OSI,RRT and transWSS)in the non-diabetic rabbit aortas were similar to those in the diabetic rabbits.However,the values of TAWSS and transWSS in the non-diabetic rabbit aortas were,in general,higher than those values in the diabetic rabbits.The back of right renal artery tended to have high OSI and RRT in both the non-diabetic and the diabetic rabbit aortas.Notably,the regions with high OSI and RRT tended to have intense turbulent flow and low WSS in most diabetic rabbit aortas.These results suggest that diabetes may lead to haemodynamic changes in the rabbit aortas.In particular,the lower TAWSS and the higher OSI within the diabetic aortas may further contribute to initiating formation of atherosclerosis.This study analyzed the mechanism and haemodynamic effects of diabetes in the descending aorta combined with the haemodynamic simulation in the pathology aspect.We researched the effects of macrovascular diseases about the diabetes through analysis and comparison of the changes of the haemodynamic parameters in the non-diabetic and diabetic rabbit aortas.Meanwhile,this study provided quantitative data for prediction and prevention of vascular diseases caused by hyperglycemia.It could provide the reference and basis in the futural clinical research.