A Method Measuring Individual Homo-nuclear Scalar Coupling Network Based On Broadband Decoupling

Nuclear magnetic resonance technology is a widely used,rapidly developing and promising technology.It has been widely used in biochemical molecular structure,medical imaging,petrochemical and other fields,and has made important contributions to the development of other disciplines.Homonuclear scalar coupling provides vital information for the conformation and structural clarification of organic chemistry and biomolecules.Due to the interaction between spins,the small scalar coupling constants,and the crowding of their respective peaks,complex spectra are produced.Therefore,it is necessary to overcome the influence between two or three spin couplings in the spin coupling concerned network,and to overcome the influence of the spin in the spin coupling concerned network on the coupling of the spin outside the network.We propose a method for measuring a single spin homonuclear scalar coupling network based on broadband decoupling.The method uses the selective pulse,PSYCHE module and three-dimensional data sampling and splicing to design the two-dimensional spectrum of the spin coupling network.The chemical shift of the spin coupled with the concerned spin is displayed directly.Dimensions,the one-to-one coupling constant of the concerned spin and its coupling spin is displayed separately in the indirect dimension,providing a simple and reliable method for accurate measurement of coupling information.1.A brief introduction to the principle and development of nuclear magnetic resonance is introduced.Then,the origin of the pure displacement technique and the main methods ZS method and PSYCHE method are introduced.Furthermore,the scalar coupling and the method of measuring the scalar coupling constant are introduced,and their advantages and disadvantages are explained.2.We introduce a method for measuring a single spin homonuclear scalar coupling network based on broadband decoupling.This method can overcome the influence of unrelated kernels,directly obtain the coupling network of the concerned nucleus,and realize F2 by introducing the third indirect dimension.The dimension is decoupled,which makes it easy to measure the scalar coupling constant and improve the resolution of the spectrum.3.It mainly introduces the meaning of the knowledge map,the background of the era and the main techniques used.It also introduces a knowledge mapping software and then use the software to analyze the references cited in this paper to obtain important authors in the fields of pure chemical shift and J-decomposition spectrum,the national distribution of these authors and the most influential journals,etc.Finally it points out the notable places in its development process and discusses the future vision of the knowledge map and makes optimistic expectations.