Numerical Simulation Of Cell Motion And Adhesion In Microvessel

The effect of red blood cells and stenosis in micro-vessel on the movement of the single cell in the two-dimensional Poiseuille flow was studied numerically,and the influence of shear rate of the flow field on cell movement behavior was discussed as well.The immersed boundary method was adopted to deal with fluid-structure interaction problems,the SMAC method was used to solve the Navier-Stokes equation,the Monte Carlo Model was applied to the simulation of the formation and fracture of adhesion bonds.The membrane of the red blood cells and the white blood cells were both treated as a hyper-elastic thin shell,while the adhesion force was calculated using the linear elastic model according to Hooke's Law.The results showed that the initial position of the cell,the shear rate,stenosis height,the value of Ht and the adhesion force had effect on the movement and deformation of single white blood cell.The research results revealed the mechanism of physiological diseases such as inflammation,thrombus,and laid the foundation for building cell biomechanics analysis platform.