Pncstress: Plant Stress-responsive Non-coding RNAs Database Construction And Application

Plants growing in nature are constantly exposed to ever-changing environmental conditions including a wide array of abiotic and biotic stress stimuli.To survive and accommodate to external conditions,plants have evolved an elaborate defense system.Non-coding RNAs(ncRNAs)are recognized as key regulatory molecules in many biological processes,including microRNAs(miRNAs),long non-coding RNAs(lncRNAs)and circular RNAs(circRNAs).Accumulating evidence indicates that ncRNAs-related mechanisms play important roles in plant stress responses.Although abundant plant stress-responsive ncRNAs have been identified,these experimentally validated results have not been gathered into a single public-domain archive.Therefore,we established PncStress(http://bis.zju.edu.cn/pncstress/)by curating experimentally validated stress-responsive ncRNAs in plants.The current version of PncStress contains 4227 entries from 114 plants covering 48 biotic and 91 abiotic stresses.For each entry,PncStress has biological information and network visualization,such as genomic position,sequence,target gene,expression pattern,experimental method and functional description.Serving as a manually curated database,PncStress will become a valuable resource in support of plant stress response research.