Studies On The Halogenation Of Substitated Acetoacetanilides And Cyclization Of Ynamide By Transition Metal-Catalyzed

In this thesis we mainly focus on the synthesis of ?,?-Dihaloamides and pyrrole-2-ol by transition metal-catalyzed.Moreover,some subsequent reactions are being explored.The content roughly divides the following three parts.The first part we concisely introduces the halogenation of 1,3-dicarbonyl compounds and acetoacetanilide.Through the exploration and research of these halogenated method methodology,we realized that the previous methods have more or less disadvantages,such as virulent reagents,high reaction temperature,long reaction time or generation of by-products that not only reduce process efficiency but also bring environmental problems.We have synthesized a,a-Dihaloamides and a-haloamides in room temperature by using cheap FeCl3/CuBr2 as halogenating agent,MnO2 as catalyst.Few literature reported the synthesis of a-haloamides.This procedure takes the advantages of simple operation,Fast reaction rate and high yield.The second part we introduce the traditional synthetic methodology and the progress of pyrrole and its derivatives.Through constant research and exploration,we has been developed for its own cyclization of 2-propargylacetoacetanilide to synthesize polysubstituted pyrrole-2-ol efficiently by using PPh3 as a ligand in presence of Acetonitrile in 100?.Few previous literature reported the synthesis of polysubstituted pyrrole-2-ol.This protocol provides a new thought for synthesis of polysubstituted pyrrole-2-ol.