Based On The "Sprinkle" Concept To The Research Of The Tiopronin Enteric Sustained-Release Capsules

In this paper,water-soluble drugs tiopronin has been selected as the model to prepare enteric sustained-release sprinkle capsules,which the sustained time is 12 hour,and then research simply the enteric sustained-release capsule of dispersible stability.This article selects the microcrystalline cellulose(MCC),hydroxypropyl methyl cellulose(HPMC)as the carrier material of the pills heart,eudragit was employed as the sustained-release and enteric coating materials.In the preparation of tiopronin enteric-coated sustained released sprinkle capsules for the first time,overcomes the drawback of water-soluble drug which is difficult to control release,and discussed the factors of enteric-coated sustained released sprinkle capsules.And preliminary discussed the influence factors that influence the enteric sustained-release micro pill release,including the pills heart,preparation technology and in vitro release.The different of sustained matrix material,the prescription of enteric-coated material and film thickness were investigated,then the optimized formulation was confirmed.The sprinkle capsules made by the optimized prescription was proved to have 12 h excellent release,the cumulative release of tiopronin was up to 92% and t the reproducibility of different batcher was good.The enteric-coated sustained-release pellets have been effected according to the optimized prescription and technology of the preparation in accordance with the specifications(150 mg),and then fill it into the sprinkle capsules,and its stability is made simple.