Study On Oxidative Coupling Reaction Of Transition Metals Catalyzed By Isonitrile

How to efficiently and selectively select molecules containing complex functional groups using cheap and readily available raw materials has been a hot topic in the field of chemistry.Amides,diketones and thioesters are widely present in many natural products and drug molecules as "star functional compounds" in organic chemistry.Chemists have been working on synthesizing these compounds for a long time.There are many related reports at present.This paper also tries to obtain target products in three parts by different reaction modes.In the first part of this thesis,some properties of isonitrile compounds,so me concepts of oxidative coupling,and some specific examples of isonitrile co mpounds involved in oxidative coupling under the action of transition metals ar e introduced.Some deficiencies in the work of the Union have proposed Palla dium/copper-catalyzed oxidative coupling of arylboronic acids with isocyanides: Selective routes to amides and diaryl ketones.The second part introduces some achievements that chemical workers have made in the field of C-N compound bond-breaking in recent years and has d eveloped a case of Copper-catalyzed alkylation of thiophenols with benzyltrimet hylammonium triflatesThe third part mainly introduces some achievements in transition metal catalysis,especially in the decarboxylation coupling of ?-benzoylformic acid compounds catalyzed by palladium compounds,and develops a photocatalysis decarboxylative coupling between ?-oxocarboxylicacids and thiophenols...