Synthesis Of Secondary Amides Through Palladium (Ⅱ)-Catalyzed Aminocarbonylation Of Arylboronic Acids With Amines/Hydrazines And CO

Amide bonds are present in a vast array of useful molecules including numerous industrially important compounds as well as bioactive natural products.Traditional methods for amide synthesis include the use of activated carboxylic acid derivatives to combined with amines.Usually,most of these methodologies are associated with significant drawbacks,such as long reaction times,harsh reaction conditions,low to moderate yields and poor atom-economy.Therefore,the developments of new and more efficient methods for amides synthesis are still under current request.Herein,we report a direct approach to prepare secondary amides with arylboronic acids,primary amines or phenylhydrazines in the presence of CO（balloon）.A facile and efficient method for Pd-catalyzed aminocarbonylation of arylboronic acids with amines to give secondary amides was developed.With Pd（dppf）Cl₂ as the catalyst,nano CuO as the oxidant,anisole as the solvent,30different amides were synthesized in good yields.This method exhibited good atom economy and showed a wide functional group tolerance.The first aminocarbonylation of arylboronic acids and phenylhydrazines to give amides in the presence of CO was described.The transformation was achieved in the catalysis of Pd（dppf）Cl₂,nano CuO as the oxidant and NaHCO₃ as base.The reaction was taken in a shlenck tube at 100 ^oC for 24 h,phenylhydrazines were approved to transformed to corresponding amines and then react with arylboronic acids and CO.A possible mechanism for this reaction was proposed in this papper.