Study On Pd-Ni@N-MPC And Its Catalytic C-C Coupling Reaction

C-C coupling reactions as an important means of constructing molecular skeleton have been widely used in the synthesis of drug molecules,small organic molecules,polymers.Though this reaction is a classical and mature model reaction in organic chemistry,people are still keen to improve the traditional catalytic system and try to use a more economical and environmentally friendly catalytic system.At present,the commonly used catalysts in C-C coupling reactions are commercialized homogeneous catalysts such a Pd(OAc)2,Pd(PPh3)4 and Pd2(dba)3.However both homogeneous catalysts and ligand are expensive,and most of the ligands are toxic and demand hash reaction conditions,moreover,the catalysts are difficult to separate from the product,all of this limits its application in industry.In recent years,many researchers have reported Pd(0)and Pd(II)complex to catalyze C-C coupling reactions,and successfully realized the recycling of the catalyst.At the same time,some catalysts prepared from cheap metals or alloys have been reported,which greatly reduced the cost of reaction.So exploring new cheap heterogeneous catalyst system is of great significance.Because ligands play a very important role in homogeneous catalysis system,we can select the appropriate supports to achieve the integration of carriers and ligands,and improve the activity of supported nano-catalyst.In recent years,with the rapid development of nanotechnology,porous materials have attracted wide attention of scientists due to their excellent physical and chemical properties.The porous carbon materials are widely used in the field of catalysis,separation and electrochemistry because of its high chemical stability,low cost,large surface area and high porosity.The chemical and physical properties can be further improved by doping nitrogen atoms.The nitriding site in the carbon carrier can enhance the interaction between the active component and the carrier,immobilized active component on the carrier.In this paper,we explored the application of the supported palladium-nickel nano catalyst in the C-C coupling reaction based on a large number of literatures.We first synthesized nitrogen doped mesoporous carbon by hydrothermal method,and the supported nano catalyst Pd-Ni@N-MPC was successfully synthesized by impregnation method.The catalyst was applied in the Suzuki coupling reaction,the Pd-Ni@N-MPC has excellent catalytic properties of halogenated benzene and bromobenzene.Compared with palladium catalyst,the doping of nickel greatly reduces the cost of the catalyst,and the catalytic performance can keep long time in the air.On this basis,we improved the preparation method of supported nano catalyst.We synthesized Pd-Ni@N-MPC by one-step synthesis in situ,and the distribution of metal nanoparticles is more uniform.The catalytic performance of the catalyst was detected by Heck reaction and Sonogashira reaction.The results show that the catalyst has good catalytic effect on aryl iodobenzene.And the advantages of easy recycling,green environmental protection are of great significance for the application of catalysts in industry.Therefore,the catalyst system displayed in this paper will have wide application prospect no matter from the environmental protection or industrial application.