Study On Preparation And Properties Of The Zn-BCP/Ti Bone Tissue Engineering Scaffold

Zinc(Zn)can enhance bio-compatibility of bone tissue engineering scaffold,which has the ability of promote the reconstruction of bone matrix.The BCP made of HA and?-TCP has good bio-compatibility and biological degradation.Composite made of BCP and titanium(Ti)with the matching mechanical properties of bone tissue and good bio-compatibility,can be used as a type of hard tissue repair scaffold materials.In this paper,a new type of Zn-BCP/Ti composite scaffold for bone tissue engineering was developed based on material synthesis,which has good academic value and medical prospect.The Zn-doped HA powder and the Zn-doped ?-TCP powder were prepared by chemical precipitating process and the heat treatment method.The effects of Zn doping on the composition,elemental composition and microstructure of HA were investigated.The results show that Zn2+ can broke the lattice of HA when the amount of Zn2+ was 20 mol%and 30 mol%.Zn2+ can successfully dope the lattice of ?-TCP when the amount of Zn2+ was below 15mol%and generated with Ca19Zn2(PO4)14.?-TCP is a better carrier of Zn than HA.The Zn-doped HA powder and the Zn-doped ?-TCP powder were mixed to prepare the Zn-BCP powder,The self-made Zn-BCP powder blended with mass ratio of 70%Ti powder.The mixed powder was pressed into billets at a pressure of 35kN.The billets was incubated at 1050? for 60 min under vacuum to fabricate the Zn-BCP/Ti bone tissue engineering scaffold.The composition,surface morphology and micro-hardness of the materials were studied by phase analysis,elemental analysis,morphological characterization and micro-hardness test.The results show that the introduction of Zn leads to the decomposition of HA to produce Cai9Zn2(PO4)14,and the material of porous network has the micro-hardness of the range of HV525 to HV553 which is matched with bone tissue.The simulated body fluid(SBF)immersion experiment of Zn-BCP/Ti composite bone tissue engineering scaffold was carried out.And the bio-activity and degradation of the materials were studied by phase analysis,morphological characterization and quality test.The results show that the Ca19Zn2(PO4)14,TiO2 and ZnO enhance the ability of mineralization and degradation of the composite scaffolds in the SBF.