| Objective: To study the effect of haze exposure on the expression of IL-35,CC16 and hs-CRP in serum of workers indoors and outdoors,and to compare the expression differences of circulating markers reflect the level of body inflammation under different haze exposure time.To explore possible mechanisms of haze exposure on the body's inflammatory and immune damage,and provide new ideas for the prevention and treatment of respiratory diseases caused by haze exposure.Methods: Early morning fasting venous blood were collected from two groups of medical examiners at People's Hospital of Hebei Province in February 2017.The survey was completed and basic information was filled in,including general information(name,sex,age,occupation,place of residence),smoking status,Drinking history,whether the cardiovascular and cerebrovascular,chronic respiratory diseases and history of autoimmune diseases,masks,purifiers and other protective measures and the use of daily average exposure to haze and so on.According to the inclusion criteria and exclusion criteria,a total of 176 qualified persons were screened out,with a total of 176 people.Depending on the working space they were divided into 87 indoor groups and 89 outdoor groups.The levels of IL-35,CC16 and Hs-CRP in serum were detected,and the results were to be incorporated and analyzed statistically.Result:1.The indoor group haze daily exposure duration is 1-4 hours,the average of daily haze exposure is 2.50 hours;outdoor group daily haze exposure duration is 8-10 hours,the average of daily haze exposureduration is 8.95 hours;Outdoor haze exposure time was significantly longer than that of the indoor group(Z=-11.456,P<0.001).2.Adopting protective measures such as an air purifier and wearing masks,42 persons in indoor group and 33 persons in outdoor group adopted protective measures of 48.3% and 37.1% respectively,with no significant difference(?2 = 2.256,P = 0.133).3.Serum levels of IL-35 in indoor group and outdoor group were269.35±9.32pg/ml and 129.44±10.87pg/ml,respectively,while those in outdoor group were lower than those in indoor group(t = 91.58,P <0.001).4.The average expression of CC16 in indoor and outdoor groups were339.35±14.42pg/ml and 207.66±13.95pg/ml,respectively,The CC16 expression level in outdoor group was lower than that in indoor group(t =61.57,P <0.001).5.Average hs-CRP levels of indoor and outdoor groups were 1.08 ±0.08pg/ml and 1.87 ± 0.07pg/ml,respectively.The serum level of hs-CRP in outdoor group was significantly higher than that in indoor group(t =-69.09,P <0.001).6.The level of IL-35 was negatively correlated with the duration of exposure in both groups.The longer the exposure time was,the lower the expression of IL-35 was(r =-0.965,P <0.001),the longer exposure time,the lower expression level of CC16(r =-0.955,P<0.001).The expression level of hs-CRP was positively correlated with the duration of exposure(r =0.955,P <0.001).Conclusion:Compared with the low exposure group,the hs-CRP level was significantly increased and the expression levels of IL-35 and CC16 were markedly decreased.Haze exposure time and serum hs-CRP expression was positively correlated with IL-35 and CC16 was negatively correlated.Outdoor air pollution triggered the body's immune response toinflammation,reduce haze exposure.The use of reasonable and effective protective measures may help health and safety benefits. |
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