Study On The Photocatalytic Reaction To Form Alkenes And ?-amides

There are a wide variety of carboxylic acids and carboxylic acid derivatives that are abundant and have a large content in nature.How to make these carboxylic acids and carboxylic acid derivatives effectively convert to higher-value chemicals is an important research area in the field of organic chemistry today.In this field,the decarboxylation reaction research is a very hot direction.It should be acknowledged that the decarboxylation coupling reaction is one of the classical means of constructing carbon-carbon bonds and carbon-other atoms bonds.Photo-catalysis is a reaction method with a long history in the field of chemistry.It has a wide range of applications and is closely related to free radical chemistry.In recent years,in the field of organic chemistry,research on photo-catalytic reactions has received much attention and has developed many new applications and new progress.For example,the photo-catalytic reaction with decarboxylation of carboxylic acid not only avoids the fatal weakness of the decarboxylation reaction which requires high temperatures,but also studies the development of ruthenium and nickel as the core,instead of the using of original catalytic systems of metals such as copper,ruthenium,rhodium,silver,palladium and gold.These great advances in the catalytic system have brought new vitality to this ancient field.In the first chapter of this paper,we focused on the development of the decarboxylation reaction.This includes the following aspects:transition metal catalyzed decarboxylation coupling reaction,decarboxylation coupling reaction under light excitation,and decarboxylation coupling reaction of carboxylic acid derivative under light excitation.We have made a fair introduction and a summary of these research findings.Unlike non-aliphatic carboxylic acids,aliphatic carboxylic acids are often more difficult to join in the decarboxylation reaction.After using photo-catalysis to successfully we have overcome the difficulty of decarboxylation of alkyl carboxylic acids.There are many studies targeting on carboxylic acid derivatives,which often have more diverse properties.In the second chapter,we introduced the photo-catalysis of the reaction of the decarboxylation to olefins of the activated redox carboxylate derivatives of aliphatic carboxylic acid derivatives which enriched the application of decarboxylation of carboxylic acid derivatives.We have conducted a detailed discussion of this reaction in terms of background,experimental methods,experimental data,and research processes.Beta-amide is a chemical structure with a strong importance,usually found in drug molecules and in a few alkaloids.In the third chapter,we have practiced a photocatalytic decarboxylation reaction involving aldehydes,amines,and keto acids to directly construct the P-amide structure.We have done a lot of other works around this reaction,including gram-level applications,chirality testing,and mechanism inference.In summary,this article attempts to use photo-catalysis to solve a decarboxylation problem.We hope to broaden the application of decarboxylation and hope to inspire more research on photo-catalytic reactions.However,we should see that there are still many more difficult problems to solve in this area,such as whether the decarboxylation coupling reaction can be combined with chiral control.These issues will enable us to continue thinking.