Application Of Photothermal Nanomaterials In Cancer Treatment

The combination of nanoparticles and traditional chemotherapeutics can achieve better results for cancer treatments.When the multifunctional nanoparticle are gathered in the tumor tissue,local temperature can be increased with an appropriate power of infrared laser radiation and anticancer drugs can be released from the nanocarriers accordingly,as a result,the tumor cells will be killed more effectively.In this paper,one-step method is used to synthesize sta-likegold nanoparticles?gold nanostars?with an average size of about 25 nm.Due to their strong surface plasmon resonance characteristics in the near-infrared region,they can effectively convert the absorbed light energy into heat,which makes them to be a kind of photothermal nanomaterial.Then,16-Mercaptohexadecanoic acid(C₆H₃₂O₂S)is modified on the surface of Au nanostars via Au-S bond to form a gold nanocomposite carrier.The specific operation is shown as follows:1.Firstly,we use the above gold nanocomposite carrier to load anticancer drug doxorubicin hydrochloride?DOX?,and then,the surface of drug-loaded nanocomplex is modified with bovine serum albumin?BSA?to increase its stability and biocompatibility.Finally,it is proved from the cell viability experiments that the drug-loaded nanocomplexes can combine chemotherapy with photothermal therapy to achieve synergistic effects during treatment of cancer.2.The photothermal conversion efficiency is increased by allowing the gold nanocomposite carrier to be loaded with a photosensitizer,Indocyanine Green?ICG?.The new nanocomposite materials are characterized by UV-Vis spectrophotometer and transmission electron microscope.At the same time,cell experiments showed that the gold nanocompositess have low cytotoxicity,and the introduction of photosensitizers can effectively reduce the minimum laser power density required during the photothermal therapy of cancer.