Interface Regulation And Biological Application Of Noble Metal Nanoparticles

With the continuous development of nanoscience,the subject has gradually penetrated into many other fields,even connected with human health.Among them,precious metal nanomaterials are easy to synthesize.The easy-to-build synthetic conditions and synthetic effects with shape can be changed have been paid more and more attention.Because of its unique physical and chemical properties,it has become a hot topic of the subject.In this paper,a variety of plasma plasmon nanoparticles were prepared based on the synthesis of noble metal nanoparticles,which were functionalized by surface modification and directional assembly techniques.In this paper,the controllable assembly process of iso-high exciton cluster structure and the regulation of interface bioactive molecules were studied.Photoacoustic imaging probes and electrochemical biosensors with excellent performance were prepared,respectively.The high resolution photoacoustic imaging of tumor tissue in vivo and the evaluation of drug efficacy were realized.An electrochemical biosensor with highly sensitive response signal for glycerol tributyrate was developed.The details are as follows:1.By modifying gold nanorods and gold nanospheres on the surface,a new type of assembly nanomaterials were prepared.On the basis of these,photoacoustic imaging experiments were carried out on nude mice with tumor.During this period,the concentration and quantity of the materials were explored.The experimental results also proved that the materials prepared by me have very good biocompatibility and photoacoustic imaging ability in vivo.It is expected to be used to evaluate the efficacy of anticancer drugs.2.On ITO glass as the sensor substrate,adsorption and fixation of bell-shaped gold nanoparticles,then polydopamine and fat An electrochemical biosensor with high sensitivity and selectivity was prepared by enzyme surface modification.The biosensor can be used for tributyric glycerol(TG).A series of rapid detection methods including electrochemical impedance spectroscopy(EIS)and cyclic voltammetry(CV)were used to verify the experimental results.The results show that because of its excellent electrochemical properties,the bell shaped gold nanoparticles have a broad application prospect in the development of new electrochemical sensors.