Study On Asymmetric Catalytic 1,6-conjugation Addition Of Para-Quinone Methides And Diazophosphate

p-Quinone methides is an important class of quinoes in organic chemistry.It has a high electrophilicity,and a prone to 1,6-conjugated addition reaction with nucleophiles,froming a chiral second aryl compounds with potential drug activity.In this thesis,a series of chiral phase transfer catalysts were designed and synthesized.It was confirmed that the cinchona-derived phase transfer catalysts were used in the asymmetric 1,6-conjugated addition reaction of p-quinone methides and diazophosphate.At present,the reaction has a good yields(up to 93%),and enantioselectivities(up to 90% ee).The novel chiral diaryl compound containing a phosphonate group has been synthesized.In order to pursue better results we are further designing new synthetic catalysts.