Nano-frameworks For Therapy Of Methicillin Resistant Staphylococcus Aureus

Nanoframework,including metal organic frameworks?MOFs?and covalent organic frameworks?COFs?,has been used as drug delivery in many studies.Some other researchers use nanoframework as photosensitizer or reagent for imaging because some nanoframework has special chemical property.Methicillin Resistant Staphylococcus aureus?MRSA?may cause many kinds of infection,for example enteritis,pneumonia,pericarditis,skin infection even systemic infection,but it is not sensitive for most drugs.As a result,it's very necessary to develop new methods for therapy MRSA.In our work,we first we describe a general approach for the construction of b-lactam antibiotics and?-lactamase inhibitors co-delivery of nanoantibiotics based on metal-carbenicillin framework-coated mesoporous silica nanoparticles?MSN?to overcome MRSA.The?-lactamase inhibitor,sulbactam,loaded in MSN and carbenicillin,a b-lactam antibiotic,was used as an organic ligand that coordinates with Fe³⁺to form a metal-carbenicillin framework to block the pores of the MSN.The nanoantibiotics had better penetration depth into biofilms and an obvious effect on the inhibition of MRSA both in vitro and in vivo.What's more,a novel type antibacterial Band-Aids combining porphyrin based COFs with a commercial antibiotics-free Band-Aids has been put forward.Under sunlight-mimicking white light irradiation,the COFs can produce effective photothermal conversion,as well as highly ROS,thereby triggering the potent hyperthermia and simultaneous ROS for killing bacteria.Because this method kills MRSA by a different way from antibiotics,it can avoid the drug resistance of MRSA.This COFs based Band-Aids was used for treating skin infection caused by MRSA.