Effect Of Major Air Pollutants On The Risk Of Ischemic Stroke Onset In Taiyuan,Shanxi Province

Objective:To analyze the impact of major air pollutants on the risk of ischemic stroke of the residents of Taiyuan City,and provide evidence for the management of air pollutants and prevention of ischemic stroke.Methods:Retrospectively Analyze the medical records of patients with acute cerebral infarction who admit the Department of Neurology ofFirst Hospital of Shanxi Medical University from December 2013 to October 2014 and live in Taiyuan for a longtime.CollectingDailyaverageconcentrationoffineparticulate matter?Aerodynamic diameter is Less than2.5umPM2.5?,inhalable particulate matter?Aerodynamic diameter is Less than10um PM10?,Sulfur dioxide,Carbon monoxide,Nitrogen dioxide and ozone,and Air quality index daily.The medical records were classified using Chinese ischemic stroke subtypes.A two-way symmetry1:4 paired case crossover study was used to establish a single-pollution model to analyze its relevance.Results:1.daily average concentration of PM_2.5.5 and PM₁₀0 increased by 10 ug/m3,and the odds ratio?OR?value of cerebral infarction after 0 to 3 days was greater than 1,and the correlation was statistically significant?P<0.001?;The optimal lag period for PM_2.5.5 is 1 day?Lag1?,the OR value is 1.008,the 95%confidence interval?CI?is?1.006 to 1.010?,and the best lag period for PM₁₀0 is 2 days?Lag2?,OR?95%CI?1.011?1.010 to 1.013?;2.SO₂ exposure had the greatest impact on the incidence of ischemic stroke on the same day,and its OR?95%CI?was 1.011?1.009 to 1.013?;3.CO was not statistically significant in relation to ischemic stroke lagging 0 to 3 days;4.For every10 ug/m3 increase in NO₂,there was no significant difference in ischemic stroke after0 days?P=0.071,P>0.05?;The OR?95%CI?in cerebral infarction after lag of 1 to 3days was greater than 1,and related statistics were obtained?P<0.05?.The best lag period was 2 days.The OR?95%CI?was 1.014?1.007 to 1.021?;5.The best lag phase for the effect of O₃ on acute cerebral infarction was 0 days,OR?95%CI?value is1.007?1.005 to 1.009?;6.Analyze the effect of daily average concentration of the best lag time of each pollutant on each subtype of cerebral infarction.PM10?Lag2?and NO2?Lag2?had the greatest impact on atherosclerotic cerebral infarction.The OR?95%CI?was 1.012?1.010 to 1.014?,1.012?1.004 to 1.020?;There was no statistically significant correlation between thromboembolic stroke and O3?Lag0??P=0.053,P>0.05?.PM2.5?Lag1?,PM10?Lag2?,SO2?Lag0?,and NO2?Lag2?were all related to cardiogenic cerebral embolism.There was statistical significance?P<0.05?,of which NO2?Lag2?had the greatest impact on it,and the OR?95%CI?was 1.028?1.009 to 1.049?.The incidence of arteriosclerotic cerebral infarction was most affected by the O3 concentration on the day.OR?95%CI?is 1.012?1.006 to1.018?;7.The CISS classification is that atherosclerotic cerebral infarction is divided into carrier arterial plaque obstruction perforator,arterial-arterial embolization,hypoperfusion/embolism clearance and mixing mechanism the four types according to the pathogenesis.The aortic atherosclerotic cerebral infarction with arterial obstruction perforator was the most affected by NO2?Lag2?,OR?95%CI?was 1.017?1.007 to 1.027?;NO2?Lag2?was not statistically significant for arterial-arterial embolization and hypoperfusion/emboli removal?P>0.05?.But,PM10?Lag2?,SO2?Lag0?had similar effects on it,with statistical significance?P<0.001?;There was a statistically significant correlation between the mixed type and PM10?Lag2??P=0.009,P<0.05?.The rest were not statistically significant.Conclusion:The best lag period for each pollutant was different for ischemic stroke;CO was not statistically significant for ischemic stroke lagging 0 to 3 days;within the optimal lag period,each pollutant has different effects on different types of cerebral infarction.