Transition Metal-Catalyzed C-H Arylation Of ?-phenylalanine Derivatives

Transition-metal-catalyzed direct transformations of aromatic C-H bonds are emerging as valuable tools in organic synthesis.These reactions are attractive because of they allow for inherently efficient construction of organic building blocks by minimizing the pre-activation of substrates.Of these processes,C-H arylation has recently received much attention due to the importance of the biaryl core in medicinal and materials chemistry.We can synthesis the target compound which is difficult to be obtained by traditional method via C-H activiation in an atom-economic manner.It is an economical and efficient approach to synthesis a complex compound by direct functionalization of C-H bond.Herein,the studies of palladium catalyzed o-C-H arylation of a-phenylalanine derivatives and therefore produce a series of arene substituted compounds was described.The main content is Pd catalyzed aromatic C-H arylation of a-phenylalanine derivates directed by pyridineamide as a targeting group.In addition to being the subunit of peptides and proteins,amino acids are employed in total synthesis and ligand elaboration as chiral building blocks,chiral ligands,or chiral catalysts.Because of their broad spectrum of applications and the limited number of amino acids genetically encoded,there is an urgent for developing new methodologies for the chemical modifications of amino acids and peptides directly.This paper aims to study Pd catalyzed C-H arylation of the amino acid derivates assisted by pyridineamide and therefore pyridineamide directed C-H arylation of a-phenylalanine for synthesis of unnatural amino acids was described.