Studies On Copper Catalytic Synthesis Of Isoquinoline-1,4-Dione,isoquinoline-1,3,4-trione Derivatives And Hydroxytrifluoromethylation Of Alkenes Enamides

Nitrogen-containing heterocycles are very important organic compounds that had been a research focus in the field of organic synthesis.In recent years,free radical chemistry research has been unprecedentedly high and it is an important means for constructing such heterocycles.Among them,nitrogen-centered radicals are very important intermediate and are widely used to synthesize various nitrogen-containing heterocyclic compounds.In addition,trifluoromethyl is a very important group in pesticides and drug molecules Therefore,the development of new free radical methodologies is of great significance for the construction of nitrogen-containing and fluorine-containing compounds.Under the guidance of these research strategies,this thesis has developed a new method for the construction of nitrogen-containing heterocycles and an effective new strategy to introduce trifluoromethyl groups into the molecule.This thesis has two parts: In the first part,the decarbonylation of copper catalyzed by nitrogen radicals is introduced.A series of isoquinolinetrione derivatives are synthesized,and a series of new heterocyclic compounds are synthesized for the first time.The second part introduces the trifluoromethyl hydroxylation of copper-catalyzed olefins,which provides a new synthesis method for the synthesis of ?-trifluoromethylenamine.A series of 3-hydroxy-2-substituted isoindolinone compounds were simultaneously synthesized.All products were identified by NMR and HRMS.Based on the experimental results,a possible mechanism was proposed for the new reaction.