Preparation And Properties Of Fibrous Membranes With Dragonfly Wing Mimetic Structure

Structures become the essential element of adjusting the mechanical properties of biomaterials as the components are limited by the certain biological repairment in tissue engineering applications.Dragonfly wing possesses unique mechanical characteristics because of its geometric vein and “membrane-vein-membrane” triple layer structure.Inspired by this,the dragonfly wing-like structure may be practicable to apply for designing tissue engineering materials with satisfactory mechanical properties.Furthermore,there is hardly any research on the mechanical properties of materials with biomimetic dragonfly-wing structure recently.One of the key points to explore the mechanical properties of the structure is to obtain a material with dragonfly wing-like structure.Electrospinning is a prevailing technique developed rapidly in recent year,which shows great potential for its applications in tissue regeneration.Owning to its ability to obtain microstructural fiber networks which are similar to native extracellular matrix(ECM)and controllable macrostructural patterned fibrous membranes,electrospinning can be developed to prepare materials with biomimetic dragonfly wing structure.It is envisaged that biomaterial with dragonfly wing mimetic structure could be prepared by electrospinning.Therefore,the preparation and properties of biomimetic structures were studies systematically in this study.The following results were achieved.1.The preparation of fibrous membrane with biomimetic dragonfly wing structure.In this study,four types of fibrous lattices with accurate geometry structure were successfully obtained by introducing insulating carriers with geometric ionic liquids as the collector to overcome the shortage of parallel deposition of fibers.The fibrous patterns were successfully obtained by using quadrilateral and hexagonal metal meshes with different width as receiving substrate.Then,the combined membranes with biomimetic hierarchical structure were also obtained by hot-pressing technology.2.The study of mechanical properties of dragonfly-vein biomimetic structure PCL fibrous membranes.These biomimetic fibrous membranes with four types of geometric lattices have their own mechanical characteristics because of their diverse structures.Wherein,membrane with Regular quadrilateral lattice presented highest mechanical properties.Membrane with Regular quadrilateral pattern in second group possessed the biggest mechanical properties in all patterns.3.The study of mechanical properties of dragonfly-wing biomimetic structure fibrous membranes.(1)The mechanical properties of combined membranes with four types of lattices were determined by their lattice structures,and membranes with Regular quadrilateral and Regular hexagon-small lattices presented improvements for the combined membranes in mechanical properties compared with non-structure triple layer membrane(TP).The patterned combined membranes showed better mechanical properties than TP.The patterned combined membranes with Regular quadrilateral in the second group possessed the highest mechanical properties in all patterned combined membranes.(2)The combined membrane added with GO or CTS shown the improvement of mechanical properties.Meanwhile,combinations of components and structures could develop combined membranes with different mechanical properties.4.The study of biological properties of biomimetic structure fibrous membranes in vitro.The PCL/CTS patterned combined membrane degraded for one month possessed a certain mechanical property.And it was demonstrated that the combined membrane was biocompatible in vitro cell experiments.The biocompatibility of the degraded composite membrane was better than that before degradation.In summary,this study not only innovates the preparation of geometric lattice structure material with precise size by wet electrospinning,but also puts forward the improvement method on mechanical properties of tissue engineering biomaterial based on biomimetic dragonfly wing structure.This study is promising to provide a new strategy and guidance for the repairment of tissues bearing forces.