Core-Shell Alginate-Graphene Oxide Hydrogel Microcapsules Based Photothermally Controlled Release Of Lidocaine

Lidocaine is one of the most commonly used Anesthetic drugs for local anesthesia during the process of dental surgery.However,its overdose symptoms may include uneven heartbeats,seizure(convulsions),slowed breathing,coma,respiratory failure(breathing stops),or numbness continues three to four hours even after surgery,which makes the patient uncomfortable.To overcome this limitation,we have fabricated macroscale drug droplets of lidocaine in a hydrogel with Graphene oxide nanoparticles by core-shell structure microparticles using coaxial electrospray method.By optimizing micro-droplets fabrication process and other parameters including liquid flow rates,applied electric voltages,and coaxial distance,we can systematically produce a stable cone-jet mode flow for lidocaine-loaded hydrogel-GO with an average size of 3?m.For inducing the drug and enhancing the controlled release of lidocaine drug,in this study,we have purposed to utilize near-infrared Photo-Induced Heat(PIH)of nanosheets(graphene oxide)to improving drug release kinetics.In previous studies related to in vitro release demonstrates that sustained release of drugs from hydrogel microcapsules are more effective than plain drug induces and the microcapsules produced by single-axial electrospray do not cause any relevant cytotoxicity.Our purpose of the study implies that lidocaine can be effectively encapsulated in a protective shell of hydrogel for controlled release kinetics using a near-infrared wavelength of 808 nm,and prevent it from overdose complications during dental procedures.