Copper-Catalyzed Amination Of 1-Naphthylamines At C8 Positions

A simple protocol for Cu???-catalyzed picolinamide directed C8-H amination of1-naphthylamine derivatives was reported.The reaction was catalyzed by Cu?OAc?₂·H₂O and oxidized by di-tert-butyl peroxide.The reaction conditions were simple and the regioselectivity was high.The reaction is not only suitable for1-naphthylamine compounds with electron-donating and electron-withdrawing groups but also for aliphatic secondary amines.Reaction materials are cheap and readily available.The reaction has wide substrates scope and high functional group compatibility?Scheme 1?.