Study On The [3+2] Annulated Reactions Of Aurones

Aurones are a very important class of compounds with a wide range of biological activities and pharmacological properties.The basic unit structure of the aurones is benzofuranone,which is present in many natural product molecules,and is also very important building blocks in organic synthesis.This thesis contains three chapters:review the annulations recation of zaomethine yieldes;study on the[3+2]annulation of aurones with alkenoate and azomethine ylides,respectivly.The chapter one:The[3+2]annulation Reactions of azomethineylidesIn this chapter,the[3+2]annulated reactions of azomethineylides were reviewed.The chapter two:triphenylphosphine catalyzed Lu's[3+2]annulation of aurones and alkenoatesIn this chapter,the PPh₃ catalyzed Lu's[3+2]annulation of aurones with alkenoates was developed to form spiro[1-benzofuran-3-one-2,5'-cyclopentene]polycyclic moiety.The usefulness of this strategy has been demonstrated by the use of a wide variety of substrates to give desired polycyclic compounds in high yield under mild and simple reaction condition.This methodology research offered a fine entry for synthesis of natural product applanatumin A and it's analogues.The chapter three:The[3+2]annulation of aurones and azomethineylidesIn this chapter,the[3+2]cycloaddition of aurones with azomethineylides has been developed successfully to produce spiro[1-benzofuran-3-one-2,3'-pyrrolidine]polycyclic compounds with hight diasteroselectivity in excellent yields?up to 96%?.The reaction conditions is mild and the substrate has good applicability.