The Study On Mesoporous Tin Oxide For Improving The Dissolution Rate And Oral Bioavailability Of Fenofibrate

ObjectiveThe purpose of this study was to prepare a mesoporous tin oxide?MSn?as a new oral nano drug delivery system to improve the dissolution rate of poorly soluble drugs,fenofibrate?FNB?,thereby increasing the oral bioavailability of FNB.MethodsIn this study,MSn with a mesoporous structure was synthesized using mesoporous silica material?SBA-15?as the template.BCS II drugs,FNB,was chosen as a model drug and was adsorbed into the channels of MSn by an adsorption method.The morphology and structure of the SBA-15 and MSn were analyzed by scanning electron microscopy?SEM?,transmission electron microscopy?TEM?and N₂ adsorption/desorption?BET?.MSn and drug-loaded MSn?FNB-MSn?samples were characterized by powder X-ray diffractometer?PXRD?,differential scanning calorimetry?DSC?and Fourier transform infrared spectroscopy?FT-IR?to explore the state of the drug in the mesopores.The biological safety of MSn was evaluate by Caco-2 cells.In vitro dissolution studies were performed to investigate the dissolution rate of FNB-MSn.The single factor method and orthogonal text were used to screen the prescription.The FNB-MSn tablets were prepared by the optimal prescription.In vivo pharmacokinetic studies were used to analyze the FNB-MSn tablets and commercial FNB tablets.ResultsStructural characterization results confirmed that the MSn was successfully replicated from the SBA-15.Detailed characterization of DSC,PXRD and FT-IR showed that FNB in the channels of MSn was present in an amorphous state.MTT assay results demonstrated that MSn had better biocompatibility.The in vitro release tests demonstrated that MSn could effectively enhance the dissolution rate of FNB.The FNB-MSn tablets was prepared by lactose as the filler,povidone?PVP?as binder,sodium carboxymethyl starch?CMS-Na?as disintegrant and magnesium stearate as lubricant.Pharmacokinetic results indicated that MSn significantly increased the oral bioavailability of FNB.ConclusionsMSn can significantly improve the dissolution rate of poorly soluble drugs and effectively enhance the oral bioavailability of poorly soluble drugs.Therefore,MSn prepared in this study had the potential as a poorly soluble drug carrier.And MSn had a good application prospect in an oral drug delivery system.