Chemical Synthesis Of Sulfide Hollow Sphere And Its Application In Theranostic Of Tumor

With the rapid development of nanotechnology and materials science,it is of great significance to develop novel inorganic nano-theranostic reagents with high efficiency and low toxicity.Nano-theranostic reagents based the hollow nanostructure of sulfide semiconductor possessed promising prospects.Herein,we reported a general method for large-scale preparation of binary or ternary metal sulfide hollow spheres.Combined with execllent structure and characteristics of various sulfides,their application in biomedical field was explored.Due to the unique hollow structure and excellent photothermal conversion properties of Bi₂S₃ hollow nanospheres,a multifunctional nanoplatform based on hollow mesoporous Bi₂S₃ nanospheres was designed and developed by loading the interior cavity of the hollow nanospheres with a DOX-loaded phase-change material（PCM,1-tetradecanol）.This nanoplatform exhibited obvious PA imaging signal and excellent efficacy of ablating tumors combing photothermal therapy and chemotherapy.In order to further improve the performance of sulfide semiconductor,we designed and constructed more complicated double shell Zn_xCd_1-xS(DS-Zn_xCd_1-xS)hollow nanospheres by the above routes.In contrast with single shell Zn_xCd_1-xS(SS-Zn_xCd_1-xS)hollow spheres,DS-Zn_xCd_1-xS hollow nanospheres greatly improve the ability of producing reactive oxygen species by Zn_xCd_1-xS,which prompting DS-Zn_xCd_1-xS further be promising as a photosensitive drug for the therapy of tumor.In the end,we successfully overcome the lattice mismatch problem of different semiconductors and constructed Zn_0.5Cd_0.5S@Bi₂S₃ heterostructure composite nanosphere by introducing the intermediate layer.Under the irradiation of external light source,Zn_0.5Cd_0.5S@Bi₂S₃ composite nanosphere could produce abundant reactive oxygen radicals,which thereby can be used as a safely therapy agent combining photodynamic and photothermal therapy in biomedical field.