Synthesis And Properties Of Nanosalts Grafted By Biocompatible Polymers

Sodium chloride plays an important role in daily life as a necessary flavoring.However,excessive salt consumption has been a global problem,raising the risk of high blood pressure,cardiovascular disease and kidney failure.Therefore,reducing the intake of salts has been paying attention to human dietary health.Moreover,sodium chloride was inclined to be agglomerated and deliquescence in humid atmosphere during the storage and transportation process,causing trouble for applications.This paper aims to synthesize edible nanosalts and apply it to the surface salt sprinkling food,such as potato chips,cookies and nuts,etc.By taking advantage of the characteristics of large specific surface area and fast dissolution rate of nanoparticles,nanosalts would improve people's perception of salty taste in a short time and reduce the excessive intake of table salt.It is worth mentioning that the nanosalts with the protection of PEG exhibit better moisture resistance.The specific work of this paper is divided into the following two parts.In the first part,we successfully prepared polyethylene glycol grafted sodium chloride nanoparticles with uniform morphology,good dispersion and high yield by ligand-assisted reprecipitation(LARP)method under ultrasound condition.NaCl nanocrystals were single-crystal structure with{100}lattice plane,which determined by transmission electron microscopy,X-ray diffraction and EDS analysis.By changing the concentration of sodium chloride,molecular weight and concentration of polyethylene glycol,the size of sodium chloride nanoparticles could be effectively controlled.FT-IR and XPS analysis were used to determine the ion-dipole interaction between the O atom in PEG and the Na~+in NaCl.On the basis of the interaction,NaCl nanoparticles with a series of biocompatible polymers were obtained,endowing the nanoparticles with different surface properties and lay a good foundation for their subsequent applications.In the second part,we characterize the solubility rate and moisture resistance of polyethylene glycol-grafted NaCl nanoparticles.Comparison of the dissolution rate of nano-sized and micro-sized NaCl particles were realized by using optical microscope,conductivity meter,ITO microelectrode and SBFI-PVA hydrogel fluorescence imaging,respectively.The results proved that NaCl nanoparticles exhibit higher dissolution rate.Moreover,we also compared the moisture resistance of nanosalts@PEG and micro-sized salts both in the macro and micro perspective,indicating the importance of ligand for improving the moisture resistance of sodium chloride.In conclusion,this paper prepared biocompatible polymers-grafted NaCl nanoparticles,combing the advantages of fast dissolution rate and better moisture resistance,which has the potential prospect to realize the universal nanosalts.