Banana Peel Derived Dendrite Shaped Au Nanomaterials With Dual Inhibition Toward Tumor Growth And Migration

Gold nanoparticles(Au NPs)have been widely used in biomedical fields due to their diverse morphology,well biocompatibility and remarkable near-infrared response characteristics.In order to prepare functional Au nanoparticles with low toxicity and high antitumor properties,we have used fruit waste(banana peel)to synthesize new dendrite-shaped gold nanoparticles and used it for the treatment of tumors.Dendrite-shaped gold nanoparticle(Au-dendrite)were synthesized through a facile hydrothermal process.The banana peel was used as both the reducing agent and the protective agent for reducing chloroauric acid to obtain Au-dendrite.The safety assessment of the Au-dendrite was conducted by CCK-8 assay and H&E staining of the mouse's heart,liver,spleen,lung and kidney.The antitumor effects were evaluated through in vitro tumor cytotoxicity experiments and in vivo treatment of animal tumors.The experiments showed that,compared with some classical Au nanomaterials,the as-synthesized gold nanocomposites have superior biocompatibility and impressive characteristics of dual inhibition toward tumor growth and migration.