| Cancer(a malignant tumor)has now become a global public health issue.Accurate diagnosis and efficient treatment of cancer has always been the focus and difficulty of the research.So far,cancer therapies are mostly focused on surgery meyhod,radiotherapy and chemotherapy.However,these methods have some limitations.With the rapid development of nanotechnology and functional nanomaterials,photothermal therapy which is a method of physical therapy based on nanomaterials has attracted significant attentions.As a minimally invasive tumor treatment technology,photothermal therapy is regarded as a promising tumor treatment technology.Therefore,the combination of photothermal therapy and chemotherapy can not only avoid the disadvantages of a single treatment,but also highly increase therapeutic efficacy owing to the synergistic effect.As a result,it is vital to design highly efficient photothermal agents and nanomaterial-based carriersBased on gold nanorods/conductive polymer composites,we have prepared GNRs/poly(o-methoxyaniline)(GNRs/POMA),GNRs/PPy/m-SiO2(GNRs/polypyrrole/m-SiO2)and GNRs/Void/PPy core/shell hybrids.Transmission electron microscopy(TEM),Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD),and ultraviolet-visible absorption spectroscopy(UV-vis)were employed to characterize the products.The photothermal performance of the nanomaterials was measured by near-infrared laser irradiation.The property of drug controlled release was determined by cumulative release rate,and the tumor therapeutic effect was evaluated by cell viability and tumor inhibition.The relationship between their morphology and photothermal properties and drug-release properties were revealed,and then the photothermal therapy and combination therapy were instructed.The main work of this paper is as follows:(1)GNRs/POMA core/shell hybrids have been synthesized by a surfactant-assisted chemical oxidation polymerization route.The relationship between the morphology and absorption band of GNRs/POMA hybrids has been revealed,and results show that the extent of temperature increment of GNRs/POMA hybrids is consistent with the absorbance at the wavelength of the light source at 808 nm.As a result,GNRs/POMA core/shell hybrids have enhanced photothermal effects and photostability compared with single GNRs,and the GNRs/POMA(5)hybrids with the highest absorbance at 808 nm exhibit the best photothermal effect.GNRs/POMA exert superior therapeutic efficacy of in vitro and in vivo photothermal therapy.(2)In order to bring in the drug encapusulation function,GNRs/PPy/m-SiO2 core/shell hybrids have been synthesized.The anticancer drug doxorubicin hydrochloride(DOX)have been encapsulated through electrostatic adsorption and ?-? interactions.The photothermal effect and drug release behavior of GNRs/PPy/m-SiO2 show that the near-infrared induced photothermal effect is beneficial to promote the drug release.Compared with GNRs//m-SiO2,GNRs/PPy//m-SiO2 have excellent synergistic efficacy and exhibit superior therapeutic efficacy of in vitro and in vivo combination therapy.(3)As m-SiO2 in GNRs/PPy/m-SiO2 show negative effect on the photothermal effect,GNRs/Void/PPy hybrids with a hollow structure have been synthesized through a sacrificial template strategy.Then a drug controlled release system by encapsulating DOX in GNRs/Void/PPy hybrids has been constructured.The result of the photothermal effect and drug release behavior of GNRs/Void/PPy hybrids with different cavity sizes show that GNRs/Void/PPy(25 nm)hybrids with large cavities have excellent efficacy in synergistic combination therapy. |
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