Study Of Synthesis Method On Allyl Sulfones With DMA

Multi-component chemical reactions(MCRs)is a class of very important organic chemical reaction(eg,Passerini reaction,Ugi reaction)which are widely applied in natural product chemistry and combinatorial chemistry due to their high atomic economy,product diversification,and being easily operated.This kind of reaction is also very consistent with the concept of green environmental protection and sustainable development advocated by modern society.Dimethylacetamide(DMA)are not only use for their dissolution properties,but also as multipurpose reagents.They participate in a number of processes and serve as a source of various building blocks giving one or more of their own atoms.In this paper,DMA is used to provide carbon synthons and sodium sulfinate salt is used to as sulfonylating agent,a series of allyl sulfone compounds are synthesized.The detail works are descried as follows:1.A three starting material four component reaction(3SM-4CR)strategy for the synthesis of ?-acyl allylic sulfones from methyl ketones,sodium sulfinates and DMA was developed.A broad range of functional groups were tolerated in this reaction system.2.Combined with the broad existence of 2-methylquinoline skeletons in medicines and materials,An efficient strategy for the preparation of ??quinoline allylic sulfones from 2-methylquinolines,sodium sulfinates and DMA has been developed.In addition,the reaction system is also applicable to 2-methylbenzothiazole compounds.3.A novel approach for the synthesis of tertiary alcohol from ??dicarbonyl compound?sodium sulfinates and DMA is decribed.In this system,three new bonds(C-C,C-S,C-O)were formed with high chemo-selectivity.This mothod affords an efficient approach for synethesis of tertiary alcohols.