Decarboxylative Coupling Reaction Of Unactivated Carbon-Oxygen Bond

In the past decade,the activation of inert carbon-oxygen bonds has been a hot topic.The fracture of carbon-oxygen bonds provides an effective way to construct carbon-carbon bonds and carbon-hetero bonds in organic synthesis.At present,the selection of decarboxylative coupling electrophiles is limited to halogenated and halogenated materials,and most of these substrates are relatively expensive and difficult to prepare.So looking for a more economical,green electrophile is the problem we are currently solving.This paper discusses the coupling of inert carbon-oxygen bonds with various reagents,as well as transition metal-catalyzed decarboxylation coupling reactions.Summarize the law and design possible routes.The aryl valerate and aryl sulfamate are used as electrophiles,potassium polyfluorocarboxylate is a nucleophilic reagent,and nickel is used as a catalyst to synthesize polyfluorinated aromatic hydrocarbons.The research of the thesis has achieved the following results:1.Decarboxylative coupling of nickel-catalyzed aryl pivalate with polyfluorocarboxylate is achieved.The conversion mechanism provides a simple and effective protection route for the synthesis of polyfluorobiphenyl compounds.And expanded the choice of decarboxylation coupling in electrophiles.2.Decarboxylative coupling of a nickel-catalyzed aryl sulfamate with a polyfluorocarboxylate is achieved.More importantly,the decarboxylation coupling of unactivated phenol derivatives has been broken.