Thesis Of Different Morphology Copper Sulfide By Interface Reaction And Mitochondrial Targeted Drug Delivery

Malignant tumors become one of the diseases that threaten human health.The molecular complexity and heterogeneity of malignant tumors have led to its becoming a barrier to the study of malignant tumors.Nowadays,there are many methods for the treatment of malignant tumors in the clinic,such as chemotherapy.Radiotherapy and surgery,but they have the disadvantages of large side effects,low targeting,and high recurrence rate.In order to overcome the deficiencies caused by the above therapies,we have synthesized a targeted drug delivery system.It can reduce the toxic side effects of drugs on normal cells,and specifically release drugs around tumor cells in a controlled and controlled manner.Effectively inhibits the proliferation of tumor cells.The biomimetic synthesis of inorganic nanomaterials has become one of the hotspots in the research of nanomaterial chemistry.In the paper,inorganic nanomaterials were synthesized by water bath method and interface method.The method is simple,the raw material price is low,and the formed product has uniform morphology and uniform particle size.Synthetic inorganic nanomaterials have good physical and chemical properties and are often used in solar cells,lithium ion batteries,optics,and electrical.In recent years,inorganic nanomaterials have also been found to be used in biomedical fields,especially in drug carriers.Broad application prospects.In this paper,we synthesize the semiconductor nanomaterial zinc sulfide and the biocompatible calcium carbonate with pollen as the organic matrix.Their load and controlled release properties as drug carriers and their activity on tumor cells were studied.The research of this thesis can be divided into the following aspects:The spheroidal single crystal zinc sulfide nanomaterials were synthesized by water bath method using the elution of lotus powder as the organic matrix.The morphology and structure of zinc sulfide were characterized by various testing methods.The test results show that the zinc sulfide material synthesized by the water bath method has uniform morphology,uniform particle size,rough surface,large specific surface area,good pH sensitivity and a large number of mesopores.These excellent properties are beneficial to zinc sulfide to Azomycin hydrochloride.The drug loading rate reached 56.87% and the loading was 0.014 mg/mg.The slow release of doxorubicin hydrochloride showed that the zinc sulfide synthesized by the experiment had good pH sensitivity,and the release rate of doxorubicin hydrochloride was the fastest at pH=5,and it was released at pH=7.4The rate of doxorubicin hydrochloride is the slowest,and this result provides an important evidence for the study of cell viability experiments.The zinc sulfide synthesized by the water bath method uses phthalocyanine green as a photosensitizing agent,and doxorubicin hydrochloride is used as an antitumor drug,and the phthalocyanine green and the doxorubicin hydrochloride are simultaneously loaded onto the zinc sulfide by electrostatic adsorption.A variety of testing methods have been used to characterize the properties of the dual-load system.The test results show that the double-loaded system has uniform morphology and uniform particle size.The controlled release of the drug showed that we were able to detect the release of doxorubicin hydrochloride from the laser-irradiated sample at a faster rate by irradiating the sample with a 808 nm near-infrared laser.This proves that the dual load system has a certain response to near-infrared light.The cell activity study showed that the sample was more inhibited by cancer cells irradiated by 808 nm infrared laser,and the amount of doxorubicin hydrochloride was also less.This further demonstrates that 808 nm infrared laser irradiation promotes the release of doxorubicin hydrochloride.