Carbon Nanocomposites-based High- Performance Electrochemical Sensor And Wearable Electronic

Health monitoring devices for accurate detection of physiological signals and health-related biomarkers attract more and more attention.Electrochemical sensors,due to their advantages of high efficiency,high sensitivity and low cost for monitoring biomarkers,have been great development in the field of health monitoring.However,realizing the highly sensitive,reliable detection of biomarkers remains challenging,especially for the simultaneous monitoring of multiple biomarkers that co-exist in biofluids.In order to overcome the above defects,based on the selection and optimization of electrode modification materials,we are committed to develop new electrode materials for construction of high-performance electrochemical sensors.Meanwhile,we designed and fabricated a flexible and wearable electrochemical sensors device with high-performance,realizing noninvasive,real-time monitoring of multiple biomarkers in biofluids.The research content as following:First,a carbon-based single metal nanocomposite was designed and fabricated to serve as a high performance electrochemical sensor for high selectivity detection of three small biomolecules.The homogeneous nickel nanoparticles(Ni NPs)with ultra-small size(~5 nm)were prepared by a simple one-pot method where the organic phase metal salts were reduced in oleylamine.Then the nickel nanoparticles were dispersed on conductive carbon black to develop carbon supported Ni NPs(Ni/C)nanocomposite with high electrical conductivity,large specific surface area,and good stability.The as-prepared material was used for the simultaneous detection of three health-related biological small molecules(ascorbic acid,dopamine,uric acid)with well-defined oxidation peaks and larger peak separation for extraordinary selectivity.Second,based on the synergistic effect of bimetal,a carbon-based bimetallic nanocomposite was designed and prepared for the simultaneous detection of various healthrelated biomarkers.The carbon-based nickel-copper bimetallic nanocomposites were prepared by combining the nickel-copper bimetallic nanoparticles synthesized by similar thermal reduction in oleylamine with conductive carbon black.Based on the synergistic effect of bimetallic nanoparticles,the as-prepared materials for serving as the electrode materials of electrochemical sensor can greatly improve the catalytic performance,endowing it with high sensitivity and stability for the simultaneous detection of a variety of biomarkers(small biomolecules and nucleic acid bases).Third,for further realizing real-time and convenient detection of human physiological parameters and signals,we designed a flexible sweat analysis patch based on conductive carbon fabric derived from commercial silk fabric for simultaneous detection of six healthrelated biomarkers in sweat.Herein,based on silk fabric-derived flexible,intrinsically Ndoped carbon textile,we designed and fabricated a flexible sweat analysis patch for noninvasive,simultaneous detection of six kinds of health-related biomarkers in sweat.The intrinsically N-doped graphitic structure and the hierarchical woven,porous structure provided carbon textile efficient electron transmission and abundant access to reactants,enabling it to serve as excellent working electrode in electrochemical sensor with high sensitivity,excellent selectivity,and good stability.As a proof of concept,we integrated the patch with the signal acquisition and transmission components,realizing real-time monitoring of multiple biomarker in sweat.Based on carbon nanocomposites,we designed and prepared a variety of high-efficiency electrochemical electrodes and constructed high-performance electrochemical sensors for simultaneous detection of a variety of health-related biomarkers.We also explored their applications in flexible and wearable health monitoring devices.This research has opened up a new direction for the application of electrochemical sensors and hold promising practical applications in real-time monitoring of human health.