Study On The Drug Ion Transfer At Liquid/Liquid Interface

In this work,the transfer behavior of a clinical drug---phenazopyridine hydrochloride at the water/1,6-dichlorhexane（W/DCH）interface modified by functionalized mesoporous silica membrane was studied by using cyclic voltammetry and differential pulse voltammetry.It is found that the phenazopyridine（PAP）can be protonated to form phenazopyridine cation（HPAP⁺）under acidic condition,which can transfer at such a membrane-modified W/DCH interface.According to the equation of Randles-Sev?ik,the diffusion coefficient of HPAP⁺in the functionalized hybrid mesoporous silica membrane was calculated to be 1.29×10^-77 cm²/s.In addition,the electrochemical response of ion-transfer of HPAP⁺at the W/DCH interface modified by functionalized hybrid mesoporous silica membrane is much higher than bare PET membrane,which can improve the electrochemical detection performance of phenazopyridine cation.Moreover,the ionic partition diagram of HPAP⁺at the W/DCH interface modified by functionalized hybrid mesoporous silica membrane was obtained by using differential pulse voltammetry,which can not only understand the distribution of HPAP⁺under different conditions（pH value and interfacial potential）,but also obtain the distribution coefficient and ion-transfer Gibbs free energy of HPAP⁺,which helps to understand the transmembrane process of HPAP⁺across biological membrane and provide a new electrochemical method to detect phenazopyridine hydrochloride.In this work,the ion transfer behavior of emodin,at a liquid/liquid interface was studied for the first time.In this work,emodin（EM）has the role of anticancer,and it is the first time to use electrochemical method（CV and DPV）to study at the liquid/liquid interface.The Ionic Partition Diagrams and distribution coefficient of EM^-ion is investigated.Polygonum cuspidatum,rumex crispus are the first time to use liquid-liquid interfacial electrochemistry method to research.Through the filter and centrifugation,the composition and content of emodin in Chinese traditional polygonum cuspidatum,rumex crispus,aloe and aloe juice were detected by electrochemical method.Due to the samples have a complex composition and low purity,UV-vis spectrophotometry can not detect emodin.Therefore,liquid/liquid interface electrochemistry is a simple,convenient and effective detection method.D-glucose,D-sucrose,urea,L-lysine,KCl,Na₂SO₄,these interferences are used to detect the effects of EM on liquid-liquid interface transfer.Experimental results show that the influence of interfering substances on the interfacial transfer of EM can be ignored.In conclusion,the membrane modified liquid/liquid interface electrochemistry method was used in this paper to investigate the transfer behavior of two kinds of drug ions on the interface.Ion distribution diagram was used as the research method to obtain the distribution coefficient of drug ions and transfer gibbs free energy and other parameters.In addition,emodin was detected by liquid/liquid interface electrochemical method,which proved to be a simple and effective detection method.This work is helpful to understand the transmembrane transport behavior of ions on biofilms.