Biological Extraction And Properties Of Biphasic Calcium Phosphate Ceramic Materials

In recent years,bone defects caused by traffic accidents and construction industry accidents have long affected people's daily lives.Experts and scholars in related fields have prepared a variety of bone repair materials for clinical medical practice,among which calcium phosphate ceramic materials are favored by experts and scholars because of their good biological activity,biocompatibility,bone conduction and osteoinductivity,and similar to the chemical composition and crystal structure of human bones.In this paper,hairtails and chub were used as experimental materials for high temperature calcination at 700?,800?and 900?.The results show that in the XRD pattern measured at the same temperature,the hairtails bone powder contains hydroxyapatite and?-TCP biphase calcium phosphate ceramic material,while the chub bone powder contains only the hydroxyapatite phase;the infrared spectrum showed that the hairtails bone powder detected a characteristic peak of?-TCP at 1122 cm^-1.X-ray fluorescence spectroscopy results show that amorphous calcium phosphate?ACP?can decompose into HA/?-TCP biphase calcium phosphate ceramic material by heating.It can be seen from the scanning electron micrograph that the particles of HA in the chub bone are short rod-shaped,while the hairtails fish bones are mainly round?-TCP particles.The Na₂P₂O₇·10H₂O solution was also used to soak the fish bones in order to obtain more?-TCP,which was used to compensate for the lack of biodegradability of hydroxyapatite,and to obtain a biphase calcium phosphate ceramic matching the growth rate of human bone.Soaking Na₄P₂O₇·10H₂O solution with fish bone,P₂O₇^4-ion in Na₄P₂O₇·10H₂O solution will react with hydroxyapatite to form NaCaPO₄ bio-absorbable ceramic and?-TCP,then NaCaPO₄ will further react with hydroxyapatite to generate?-TCP,thereby obtaining a large amount of?-TCP.In this chapter,five different concentrations of Na₄P₂O₇·10H₂O solution were used to soak the fish bones.After the experiment,it was found to be the best when the concentration of the soaking solution was 0.06mol/L.In the last part of this paper,a porous biphase calcium phosphate bioceramic scaffold was prepared by organic foam impregnation.Firstly,several polyurethane foam carriers of the same size?2 cm×2 cm×2 cm?were prepared,and then polyvinyl butyral?PVB?was used as a binder,and the fish bone powder and absolute ethanol were slurried in a certain ratio.The polyurethane foams were then immersed into the slurry for different times and calcined at different temperatures for comparative analysis.It was found that when the calcination temperature was 1250?,the mechanical properties of the ceramic sintered body were the best?0.4951MPa?,and the porosity?47%?also reached the requirements of the bone tissue engineering scaffold?45%-55%?.When the number of times of immersion is the same?both are 5 times?,the mechanical properties are the best at the sintering temperature of 1250?,and the porosity is also high.In the preparation of porous bioceramic scaffold,the difference in calcination temperature and the number of impregnations will affect the mechanical properties and porosity of the ceramic sintered body,and the mechanical properties will increase,which will result in the material becoming dense and the porosity will be reduced.Therefore,by controlling the calcination temperature and the number of impregnations,a high quality porous bioceramic scaffold can be prepared.