Preparation And Properties Of Biomedical Antimicrobial Hydrogel Wound Dressings And Tubular Hydrogels

Hydrogels are widely used as tissue adhesives,tissue engineered cell scaffolds,wound dressings and other biomedical materials due to their high water content,good biocompatibility and various functions.These practical applications require hydrogels to have certain functional and mechanical properties,but it is difficult to achieve both.The main idea of this work is to prepare a series of hydrogels with both mechanical and antimicrobial properties by introducing antibacterial components into traditional acrylamide hydrogels and combining with the design of structural network.The main contents and results of this work are as follows:1.A new antibacterial chitosan quaternary ammonium salt(HTCC)-PAM-AgNPs hydrogel was prepared by one-pot method.Without the addition of photo-initiator,the polymerization of AM and the formation of AgNPs were completed simultaneously under ultraviolet irradiation,with simple raw materials and convenient preparation.Mechanical property test,swelling ratio test,antibacterial test and cytotoxicity test have proved that the hydrogel has excellent mechanical properties,swelling performance,antibacterial performance and biocompatibility.Animal experiments have further proved that it can effectively prevent wound infection,maintain the wound in the appropriate microenvironment,and promote wound healing.2.DOPA-MPTC-NIPAM hydrogel with antibacterial activity was prepared by copolymerization of methacrylamide dopamine(DOPA),methacrylamide propyl trimethylammonium chloride(MPTC)and NIPAM.The structure of DOPA catechol enables the hydrogel to adhere to the human epidermis well,and the copolymerization of NIPAM and DOPA makes the adhesion of the hydrogel controllable.The positive charge of MPTC gives the hydrogel antibacterial activity.The hydrogel has potential applications in wound dressings,drug controlled release materials and tissue adhesion.3.Tube hydrogels were prepared by controlled growth method using the blocking polymerization of tannic acid(TA).Ultra-high strength TA/MPTC/AM-polyvinyl alcohol(PVA)tubular hydrogels with antibacterial properties were prepared by the double enhancement method.The first enhancement was the construction of double-network hydrogels.TA/MPTC/AM was used as the first layer network to realize the controllable growth of hydrogels.The hydrogels were enhanced by enzyme catalyzed mineralization.TA/MPTC/AM-PVA hydrogel has potential applications in cell culture and vascular tissue replacement due to its special tubular structure,excellent mechanical properties and antibacterial properties.